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水痘-带状疱疹病毒所致出血性脑膜炎:一例临床、细胞学及影像学相关性病例报告

Hemorrhagic Meningitis Due to Varicella-Zoster Virus: A Case Report With Clinical, Cytologic, and Radiologic Correlation.

作者信息

Gorolay Vineet, Martens David, Satgunaseelan Laveniya, Van Camp Louise, Winkler Gemma

机构信息

Department of Radiology, Royal Prince Alfred Hospital, Sydney, AUS.

Department of Rheumatology, Royal Prince Alfred Hospital, Sydney, AUS.

出版信息

Cureus. 2022 Nov 5;14(11):e31113. doi: 10.7759/cureus.31113. eCollection 2022 Nov.

Abstract

Although varicella-zoster virus (VZV) is known to affect the central nervous system in a protean manner, hemorrhagic VZV meningitis has not been well documented in the literature. Here, we correlate the clinical, cytologic, and radiologic findings in an immunocompromised patient presenting with subarachnoid hemorrhage associated with VZV meningitis. Clinical findings included multidermatomal zoster, myelitis, and neurapraxia. Magnetic resonance imaging findings included superficial siderosis and diffused linear and nodular leptomeningeal enhancement. Cerebrospinal fluid cytology revealed hemorrhage and lymphocytic pleocytosis. This case report adds hemorrhagic meningitis to the spectrum of complications associated with disseminated VZV infection.

摘要

虽然已知水痘带状疱疹病毒(VZV)会以多种方式影响中枢神经系统,但出血性VZV脑膜炎在文献中尚无充分记载。在此,我们将一名免疫功能低下患者出现的与VZV脑膜炎相关的蛛网膜下腔出血的临床、细胞学和影像学检查结果进行关联分析。临床检查结果包括多皮节带状疱疹、脊髓炎和神经失用症。磁共振成像结果包括表面铁沉积以及弥漫性线性和结节状软脑膜强化。脑脊液细胞学检查显示有出血和淋巴细胞增多。本病例报告将出血性脑膜炎纳入与播散性VZV感染相关的并发症范围。

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