文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

NLRP3 与肠道微生物组稳态：研究进展。

NLRP3 and Gut Microbiota Homeostasis: Progress in Research.

机构信息

Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.

Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin 150081, China.

出版信息

Cells. 2022 Nov 24;11(23):3758. doi: 10.3390/cells11233758.

DOI:10.3390/cells11233758
PMID:36497018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9739202/
Abstract

The inflammasome is a platform for inflammatory signaling, and the NLRP3 inflammasome recognizes stimuli in vitro and in vivo, and releases inflammatory cytokines that trigger inflammation and pyroptosis. In the gut, the NLRP3 inflammasome is a key sensor for protecting the body from damage and exogenous pathogens. It plays a fundamental role in maintaining the stability of the gut's immune system. We focus on the role of NLRP3 as a key node in maintaining the homeostasis of gut microbiota which has not been fully highlighted in the past; gut microbiota and innate immunity, as well as the NLRP3 inflammasome, are discussed in this article.

摘要

炎症小体是炎症信号转导的平台，NLRP3 炎症小体在体外和体内识别刺激物，并释放引发炎症和细胞焦亡的炎症细胞因子。在肠道中，NLRP3 炎症小体是保护机体免受损伤和外源性病原体的关键传感器。它在维持肠道免疫系统的稳定性方面发挥着基础性作用。我们关注的是 NLRP3 作为维持肠道微生物组内稳态的关键节点的作用，这在过去并未得到充分强调；本文讨论了肠道微生物组和先天免疫以及 NLRP3 炎症小体。

相似文献

[1]
NLRP3 and Gut Microbiota Homeostasis: Progress in Research.

Cells. 2022-11-24

[2]
The crosstalk between NLRP3 inflammasome and gut microbiome in atherosclerosis.

Pharmacol Res. 2022-7

[3]
The relationship between atrial fibrillation and NLRP3 inflammasome: a gut microbiota perspective.

Front Immunol. 2023

[4]
Interplay between Gut Microbiota and NLRP3 Inflammasome in Intracerebral Hemorrhage.

Nutrients. 2022-12-9

[5]
NLRP3 Inflammasome and Inflammatory Bowel Disease.

Front Immunol. 2019-2-28

[6]
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota.

J Ethnopharmacol. 2024-6-28

[7]
The role of the microbiome and the NLRP3 inflammasome in the gut and lung.

J Leukoc Biol. 2020-9

[8]
Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens.

Int J Mol Sci. 2024-6-18

[9]
Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes.

Biomolecules. 2019-12-9

[10]
DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota.

Pathog Dis. 2016-6

引用本文的文献

[1]
Mechanisms of NLRP3 inflammasome in chronic kidney disease and the effects of traditional Chinese medicines.

Ren Fail. 2025-12

[2]
The role of probiotics, prebiotics, and postbiotics: cellular and molecular pathways activated on glial cells in Alzheimer's disease.

Front Neurosci. 2025-6-25

[3]
Regulation of pyroptosis by natural products in ulcerative colitis: mechanisms and therapeutic potential.

Front Pharmacol. 2025-4-9

[4]
Advances in kidney disease: pathogenesis and therapeutic targets.

Front Med (Lausanne). 2025-2-14

[5]
Gut microbiota in health and disease: advances and future prospects.

MedComm (2020). 2024-11-20

[6]
Differential Reshaping of Skin and Intestinal Microbiota by Stocking Density and Oxygen Availability in Farmed Gilthead Sea Bream (): A Behavioral and Network-Based Integrative Approach.

Microorganisms. 2024-7-2

[7]
[2, 6-dimethoxy-1, 4-benzoquinone alleviates septic shock in mice by inhibiting NLRP3 inflammasome activation].

Nan Fang Yi Ke Da Xue Xue Bao. 2024-6-20

[8]
Gut Microbiota Alleviates Intestinal Injury Induced by Extended Exposure to Light via Inhibiting the Activation of NLRP3 Inflammasome in Broiler Chickens.

Int J Mol Sci. 2024-6-18

[9]
Ferroptosis, Inflammation, and Microbiome Alterations in the Intestine in the Göttingen Minipig Model of Hematopoietic-Acute Radiation Syndrome.

Int J Mol Sci. 2024-4-20

[10]
Intestinal microbiota regulates the gut-thyroid axis: the new dawn of improving Hashimoto thyroiditis.

Clin Exp Med. 2024-2-22

本文引用的文献

[1]
Sex- and age-related trajectories of the adult human gut microbiota shared across populations of different ethnicities.

Nat Aging. 2021-1

[2]
Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis.

Nat Biomed Eng. 2022-7

[3]
Efficacy of Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome at 3 Years After Transplantation.

Gastroenterology. 2022-10

[4]
Specific NLRP3 Inflammasome Assembling and Regulation in Neutrophils: Relevance in Inflammatory and Infectious Diseases.

Cells. 2022-4-1

[5]
The Stickland Reaction Precursor -4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal .

mSphere. 2022-4-27

[6]
IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence.

Nat Commun. 2022-2-15

[7]
Intrinsic Radical Species Scavenging Activities of Tea Polyphenols Nanoparticles Block Pyroptosis in Endotoxin-Induced Sepsis.

ACS Nano. 2022-2-22

[8]
Maternal pre-pregnancy overweight and neonatal gut bacterial colonization are associated with cognitive development and gut microbiota composition in pre-school-age offspring.

Brain Behav Immun. 2022-2

[9]
Systematic review: the association between the gut microbiota and medical therapies in inflammatory bowel disease.

Aliment Pharmacol Ther. 2022-1

[10]
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity.

Molecules. 2021-10-8

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索