父源性 HLA-G 多态性与可溶性 HLA-G 表达及其在反复着床失败中的作用：系统评价和荟萃分析。
Association of parental HLA-G polymorphisms with soluble HLA-G expressions and their roles on recurrent implantation failure: A systematic review and meta-analysis.
机构信息
Department of Gynecology and Obstetrics, The Fourth Changsha Hospital, Changsha, China.
Department of Gynecology and Obstetrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
出版信息
Front Immunol. 2022 Dec 1;13:988370. doi: 10.3389/fimmu.2022.988370. eCollection 2022.
INTRODUCTION
HLA-G plays a central role in immune tolerance at the maternal-fetal interface. The HLA-G gene is characterized by low allelic polymorphism and restricted tissue expression compared with classical HLA genes. HLA-G polymorphism is associated with HLA-G expression and linked to pregnancy complications. However, the association of parental HLA-G polymorphisms with soluble HLA-G (sHLA-G) expression and their roles in recurrent implantation failure (RIF) is unclear. The study aims to systematically review the association of HLA-G polymorphisms with RIF, the association of sHLA-G expression with RIF, and the association of HLA-G polymorphisms with sHLA-G expressions in patients attending fertilization (IVF) treatment.
METHODS
Studies that evaluated the association of HLA-G polymorphisms with RIF, the association between sHLA-G expression with RIF, and the association between HLA-G polymorphisms with sHLA-G expressions in patients attending IVF treatment were included. Meta-analysis was performed by random-effect models. Sensitivity analysis was performed by excluding one study each time. Subgroup analysis was performed based on ethnicity.
RESULTS
HLA-G 14bp ins variant is associated with a lower expression of sHLA-G in seminal or blood plasma of couples attending IVF treatment. The maternal HLA-G010101 and paternal HLA-G010102 alleles are associated with RIF risk compared to other alleles. However, single maternal HLA-G 14bp ins/del polymorphism, HLA-G -725 C>G/T polymorphism, or circulating sHLA-G concentration was not significantly associated with RIF in the general population. HLA-G 14bp ins/ins homozygous genotype or ins variant was associated with a higher risk of RIF in the Caucasian population.
DISCUSSION
Specific HLA-G alleles or HLA-G polymorphisms are associated with sHLA-G expression in couples attending IVF treatment. Several HLA-G polymorphisms may be related to RIF, considering different ethnic backgrounds. A combined genetic effect should be considered in future studies to confirm the association of HLA-G polymorphisms and sHLA-G expressions in relation to RIF.
简介
HLA-G 在母胎界面的免疫耐受中发挥核心作用。与经典 HLA 基因相比，HLA-G 基因的等位基因多态性较低，组织表达受限。HLA-G 多态性与 HLA-G 表达相关，并与妊娠并发症相关。然而，父母 HLA-G 多态性与可溶性 HLA-G（sHLA-G）表达的关系及其在复发性植入失败（RIF）中的作用尚不清楚。本研究旨在系统综述 HLA-G 多态性与 RIF 的关系、sHLA-G 表达与 RIF 的关系，以及 HLA-G 多态性与接受体外受精（IVF）治疗患者 sHLA-G 表达的关系。
方法
纳入评估 HLA-G 多态性与 RIF 的关系、sHLA-G 表达与 RIF 的关系，以及接受 IVF 治疗患者 HLA-G 多态性与 sHLA-G 表达关系的研究。采用随机效应模型进行荟萃分析。每次排除一项研究进行敏感性分析。基于种族进行亚组分析。
结果
HLA-G 14bp ins 变异与接受 IVF 治疗的夫妇的精液或血浆中 sHLA-G 的表达较低相关。与其他等位基因相比，母体 HLA-G010101 和父体 HLA-G010102 等位基因与 RIF 风险相关。然而，在一般人群中，母体 HLA-G 14bp ins/del 多态性、HLA-G-725 C>G/T 多态性或循环 sHLA-G 浓度与 RIF 无显著相关性。HLA-G 14bp ins/ins 纯合基因型或 ins 变异与白种人群 RIF 风险增加相关。
讨论
特定的 HLA-G 等位基因或 HLA-G 多态性与接受 IVF 治疗的夫妇的 sHLA-G 表达相关。考虑到不同的种族背景，几种 HLA-G 多态性可能与 RIF 相关。在未来的研究中，应考虑联合遗传效应，以确认 HLA-G 多态性和 sHLA-G 表达与 RIF 之间的关系。
Zotero 插件