Safigholi Habib, Chamberland Marc J P, Taylor Randle E P, Martinov Martin P, Rogers D W O, Thomson Rowan M
Carleton Laboratory for Radiotherapy Physics (CLRP), Department of Physics, Carleton University, Ottawa, Ontario, Canada.
Med Phys. 2023 Mar;50(3):1928-1941. doi: 10.1002/mp.16176. Epub 2023 Jan 20.
To update and extend version 2 of the Carleton Laboratory for Radiotherapy Physics (CLRP) TG-43 dosimetry database (CLRP_TG43v2) for high-energy (HE, ≥50 keV) brachytherapy sources (1 Yb, 23 Ir, 5 Cs, and 4 Co) using egs_brachy, an open-source EGSnrc application. A comprehensive dataset of TG-43 parameters is compiled, including detailed source descriptions, dose-rate constants, radial dose functions, 1D and 2D anisotropy functions, along-away dose-rate tables, Primary and Scatter Separated (PSS) dose tables, and mean photon energies escaping each source. The database also documents the source models which are freely distributed with egs_brachy.
Datasets are calculated after a recoding of the source geometries using the egs++ geometry package and its egs_brachy extensions. Air kerma per history is calculated in a 10 0.05 cm voxel located 100 cm from the source along the transverse axis and then corrected for the lateral and thickness dimensions of the scoring voxel to give the air kerma on the central axis at a point 100 cm from the source's mid-point. Full-scatter water phantoms with varying voxel resolutions in cylindrical coordinates are used for dose calculations. Most data (except for Co) are based on the assumption of charged particle equilibrium and ignore the potentially large effects of electron transport very close to the source and dose from initial beta particles. These effects are evaluated for four representative sources. For validation, data are compared to those from CLRP_TG43v1 and published data.
Data are available at https://physics.carleton.ca/clrp/egs_brachy/seed_database_v2 or http://doi.org/10.22215/clrp/tg43v2 including in Excel (.xlsx) spreadsheets, and are presented graphically in comparisons to previously published data for each source.
The CLRP_TG43v2 database has applications in research, dosimetry, and brachytherapy planning. This comprehensive update provides the medical physics community with more precise and in some cases more accurate Monte Carlo (MC) TG-43 dose calculation parameters, as well as fully benchmarked and described source models which are distributed with egs_brachy.
使用开源的EGSnrc应用程序egs_brachy,更新并扩展卡尔顿放射治疗物理实验室(CLRP)的高能(HE,≥50 keV)近距离放射治疗源(1个镱、23个铱、5个铯和4个钴)的TG-43剂量测定数据库(CLRP_TG43v2)。编制了一个全面的TG-43参数数据集,包括详细的源描述、剂量率常数、径向剂量函数、一维和二维各向异性函数、沿-离轴剂量率表、原发射线与散射线分离(PSS)剂量表,以及从每个源逸出的平均光子能量。该数据库还记录了随egs_brachy免费分发的源模型。
使用egs++几何包及其egs_brachy扩展对源几何结构进行重新编码后计算数据集。在沿横轴距源100 cm处的一个10×0.05 cm的体素中计算每个历史的空气比释动能,然后针对计分体素的横向和厚度尺寸进行校正,以给出在距源中点100 cm处中心轴上的空气比释动能。在柱坐标系中使用具有不同体素分辨率的全散射水体模进行剂量计算。大多数数据(除钴外)基于带电粒子平衡的假设,忽略了非常靠近源处电子输运和初始β粒子剂量的潜在重大影响。对四个代表性源评估了这些影响。为进行验证,将数据与CLRP_TG43v1的数据和已发表的数据进行比较。
CLRP_TG43v2数据库在研究、剂量测定和近距离放射治疗计划中有应用。这一全面更新为医学物理界提供了更精确且在某些情况下更准确的蒙特卡罗(MC)TG-43剂量计算参数,以及随egs_brachy分发的经过充分基准测试和描述的源模型。