Suppr超能文献

[前庭神经鞘瘤的非手术治疗研究进展]

[Research progress on non-surgical treatment of vestibular schwannomas].

作者信息

Xu Maoxiang, Jiang Yumeng, Yao Qingxiu, Yu Dongzhen

机构信息

Department of Otorhinolaryngology Head and Neck Surgery,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,200233,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec;36(12):971-976. doi: 10.13201/j.issn.2096-7993.2022.12.017.

Abstract

At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective conditions of patients, a non-surgical treatment modality, namely stereotactic radiotherapy, has gradually been included in the treatment of vestibular schwannomas. Studies have shown that Gamma Knife therapy has a more prominent therapeutic effect on smaller tumors and can alleviate facial nerve disorders caused by space occupying of tumor mass. Cyberknife not only has a better effect on tumor control, but also has an ideal retention rate for patients' auditory function. Proton beam therapy has also been gradually applied to the treatment of vestibular schwannomas, but the effect of treatment remains to be further studied. Drug therapy includes a variety of target inhibitors and anti-angiogenic drugs. At present, drug treatment focuses more on preclinical research. This article reviews the clinical research of various radiotherapy and the progress of drug treatment.

摘要

目前,前庭神经鞘瘤的主要治疗方法是手术。考虑到手术存在多种并发症风险以及患者的主观和客观条件,一种非手术治疗方式,即立体定向放射治疗,已逐渐被纳入前庭神经鞘瘤的治疗中。研究表明,伽玛刀治疗对较小肿瘤具有更显著的治疗效果,并且可以缓解肿瘤占位引起的面神经障碍。射波刀不仅对肿瘤控制效果较好,而且对患者听觉功能的保留率也较为理想。质子束治疗也已逐渐应用于前庭神经鞘瘤的治疗,但治疗效果仍有待进一步研究。药物治疗包括多种靶向抑制剂和抗血管生成药物。目前,药物治疗更多地集中在临床前研究。本文综述了各种放射治疗的临床研究以及药物治疗的进展。

相似文献

1
[Research progress on non-surgical treatment of vestibular schwannomas].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec;36(12):971-976. doi: 10.13201/j.issn.2096-7993.2022.12.017.
3
Gamma Knife radiosurgery for larger-volume vestibular schwannomas. Clinical article.
J Neurosurg. 2011 Mar;114(3):801-7. doi: 10.3171/2010.8.JNS10674. Epub 2010 Aug 27.
6
Facial nerve preservation after vestibular schwannoma Gamma Knife radiosurgery.
J Neurooncol. 2009 May;93(1):41-8. doi: 10.1007/s11060-009-9842-3. Epub 2009 May 9.
7
[First experience of stereotactic radiation therapy for vestibular schwannoma using CyberKnife].
Zh Vopr Neirokhir Im N N Burdenko. 2012;76(1):13-20; discussion 20.
8
Safety and Efficacy of Gamma Knife Radiosurgery for the Management of Koos Grade 4 Vestibular Schwannomas.
Neurosurgery. 2016 Apr;78(4):521-30. doi: 10.1227/NEU.0000000000001154.
9
Stereotactic radiotherapy in three weekly fractions for the management of vestibular schwannomas.
Am J Otolaryngol. 2018 Sep-Oct;39(5):561-566. doi: 10.1016/j.amjoto.2018.06.017. Epub 2018 Jun 22.
10
Functional Preservation After Planned Partial Resection Followed by Gamma Knife Radiosurgery for Large Vestibular Schwannomas.
World Neurosurg. 2015 Aug;84(2):292-300. doi: 10.1016/j.wneu.2015.03.012. Epub 2015 Mar 16.

引用本文的文献

1
[Facial nerve protection in surgery for rare tumors of the internal auditory canal].
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 May;38(5):400-404;410. doi: 10.13201/j.issn.2096-7993.2024.05.010.

本文引用的文献

2
Outcome and Toxicity of Proton Therapy for Vestibular Schwannoma: A Cohort Study.
Otol Neurotol. 2021 Dec 1;42(10):1560-1571. doi: 10.1097/MAO.0000000000003313.
3
Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth.
Nat Chem Biol. 2021 Oct;17(10):1065-1074. doi: 10.1038/s41589-021-00813-7. Epub 2021 Jun 24.
4
RTK Inhibitors in Melanoma: From Bench to Bedside.
Cancers (Basel). 2021 Apr 2;13(7):1685. doi: 10.3390/cancers13071685.
5
The Effect of Tumor Size on Likelihood of Hearing Preservation After Retrosigmoid Vestibular Schwannoma Resection.
Otol Neurotol. 2020 Dec;41(10):e1333-e1339. doi: 10.1097/MAO.0000000000002882.
7
Histone Deacetylase Inhibitors and Papillary Thyroid Cancer.
Curr Pharm Des. 2021;27(18):2199-2208. doi: 10.2174/1381612826666201211112234.
8
Determinants of Vestibular Schwannoma Growth.
Otol Neurotol. 2021 Jun 1;42(5):746-754. doi: 10.1097/MAO.0000000000003043.
10
A comparative study of RTK gene status between primary tumors, lymph-node metastases, and Krukenberg tumors.
Mod Pathol. 2021 Jan;34(1):42-50. doi: 10.1038/s41379-020-0636-7. Epub 2020 Jul 30.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验