Xu Maoxiang, Jiang Yumeng, Yao Qingxiu, Yu Dongzhen
Department of Otorhinolaryngology Head and Neck Surgery,Shanghai Jiao Tong University Affiliated Sixth People's Hospital,Shanghai,200233,China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Dec;36(12):971-976. doi: 10.13201/j.issn.2096-7993.2022.12.017.
At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective conditions of patients, a non-surgical treatment modality, namely stereotactic radiotherapy, has gradually been included in the treatment of vestibular schwannomas. Studies have shown that Gamma Knife therapy has a more prominent therapeutic effect on smaller tumors and can alleviate facial nerve disorders caused by space occupying of tumor mass. Cyberknife not only has a better effect on tumor control, but also has an ideal retention rate for patients' auditory function. Proton beam therapy has also been gradually applied to the treatment of vestibular schwannomas, but the effect of treatment remains to be further studied. Drug therapy includes a variety of target inhibitors and anti-angiogenic drugs. At present, drug treatment focuses more on preclinical research. This article reviews the clinical research of various radiotherapy and the progress of drug treatment.
目前,前庭神经鞘瘤的主要治疗方法是手术。考虑到手术存在多种并发症风险以及患者的主观和客观条件,一种非手术治疗方式,即立体定向放射治疗,已逐渐被纳入前庭神经鞘瘤的治疗中。研究表明,伽玛刀治疗对较小肿瘤具有更显著的治疗效果,并且可以缓解肿瘤占位引起的面神经障碍。射波刀不仅对肿瘤控制效果较好,而且对患者听觉功能的保留率也较为理想。质子束治疗也已逐渐应用于前庭神经鞘瘤的治疗,但治疗效果仍有待进一步研究。药物治疗包括多种靶向抑制剂和抗血管生成药物。目前,药物治疗更多地集中在临床前研究。本文综述了各种放射治疗的临床研究以及药物治疗的进展。