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垂直腔面发射激光器（VCSEL）在生物传感原子磁力计中的应用。

Application of VCSEL in Bio-Sensing Atomic Magnetometers.

机构信息

School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China.

Beihang Hangzhou Innovation Institute Yuhang, Xixi Octagon City, Yuhang District, Hangzhou 310023, China.

出版信息

Biosensors (Basel). 2022 Nov 30;12(12):1098. doi: 10.3390/bios12121098.

DOI:10.3390/bios12121098
PMID:36551063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9775631/
Abstract

Recent years have seen rapid development of chip-scale atomic devices due to their great potential in the field of biomedical imaging, namely chip-scale atomic magnetometers that enable high resolution magnetocardiography (MCG) and magnetoencephalography (MEG). For atomic devices of this kind, vertical cavity surface emitting lasers (VCSELs) have become the most crucial components as integrated pumping sources, which are attracting growing interest. In this paper, the application of VCSELs in chip-scale atomic devices are reviewed, where VCSELs are integrated in various atomic bio-sensing devices with different operating environments. Secondly, the mode and polarization control of VCSELs in the specific applications are reviewed with their pros and cons discussed. In addition, various packaging of VCSEL based on different atomic devices in pursuit of miniaturization and precision measurement are reviewed and discussed. Finally, the VCSEL-based chip-scale atomic magnetometers utilized for cardiac and brain magnetometry are reviewed in detail. Nowadays, biosensors with chip integration, low power consumption, and high sensitivity are undergoing rapid industrialization, due to the growing market of medical instrumentation and portable health monitoring. It is promising that VCSEL-integrated chip-scale atomic biosensors as featured applications of this kind may experience extensive development in the near future.

摘要

近年来，由于在生物医学成像领域具有巨大的潜力，芯片级原子设备得到了快速发展，例如芯片级原子磁力计，可实现高分辨率磁心图（MCG）和脑磁图（MEG）。对于这种原子设备，垂直腔面发射激光器（VCSEL）已成为集成泵浦源的最关键组件，这引起了越来越多的关注。本文综述了 VCSEL 在芯片级原子设备中的应用，其中 VCSEL 被集成在具有不同工作环境的各种原子生物传感设备中。其次，本文综述了 VCSEL 在特定应用中的模式和偏振控制，并讨论了它们的优缺点。此外，还综述和讨论了基于不同原子设备的各种 VCSEL 封装，以追求小型化和精密测量。最后，详细回顾了用于心脏和大脑磁测量的基于 VCSEL 的芯片级原子磁力计。如今，由于医疗仪器和便携式健康监测市场的增长，具有芯片集成、低功耗和高灵敏度的生物传感器正在快速工业化。VCSEL 集成的芯片级原子生物传感器作为这种应用的特色应用，有望在不久的将来得到广泛发展。

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2
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Opt Express. 2022 Jun 20;30(13):23587-23599. doi: 10.1364/OE.458827.
3
Single beam Cs-Ne SERF atomic magnetometer with the laser power differential method.采用激光功率差分法的单光束铯-氖自旋交换弛豫自由原子磁力仪
Opt Express. 2022 May 9;30(10):16541-16552. doi: 10.1364/OE.450571.
4
Integrated Polarization-Splitting Grating Coupler for Chip-Scale Atomic Magnetometer.用于片上原子磁力计的集成偏振分光光栅耦合器。
Biosensors (Basel). 2022 Jul 15;12(7):529. doi: 10.3390/bios12070529.
5
Wearable OPM-MEG: A changing landscape for epilepsy.可穿戴 OPM-MEG：癫痫的新局面。
Epilepsia. 2022 Nov;63(11):2745-2753. doi: 10.1111/epi.17368. Epub 2022 Aug 9.
6
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Opt Express. 2022 Mar 14;30(6):8991-8999. doi: 10.1364/OE.450118.
7
Interference suppression techniques for OPM-based MEG: Opportunities and challenges.基于 OPM 的脑磁图（MEG）的干扰抑制技术：机遇与挑战。
Neuroimage. 2022 Feb 15;247:118834. doi: 10.1016/j.neuroimage.2021.118834. Epub 2021 Dec 18.
8
Cross-Axis projection error in optically pumped magnetometers and its implication for magnetoencephalography systems.光泵磁强计中的交叉轴投影误差及其对脑磁图系统的影响。
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9
Modelling optically pumped magnetometer interference in MEG as a spatially homogeneous magnetic field.将光学泵磁强计干扰模型化为 MEG 中的空间均匀磁场。
Neuroimage. 2021 Dec 1;244:118484. doi: 10.1016/j.neuroimage.2021.118484. Epub 2021 Aug 19.
10
A study of scalar optically-pumped magnetometers for use in magnetoencephalography without shielding.用于无屏蔽脑磁图的标量光泵磁力仪研究。
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