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原发性醛固酮增多症对超声图像中颈动脉纹理的影响。

The Effect of Primary Aldosteronism on Carotid Artery Texture in Ultrasound Images.

作者信息

Kaushik Sumit, Majtan Bohumil, Holaj Robert, Baručić Denis, Kološová Barbora, Widimský Jiří, Kybic Jan

机构信息

Faculty of Electrical Engineering, Czech Technical University in Prague, Karlovo Náměstí 293/13, 12 000 Prague, Czech Republic.

Penta Hospitals CZ, Nemocnice Ostrov, U Nemocnice 1161, 363 01 Ostrov, Czech Republic.

出版信息

Diagnostics (Basel). 2022 Dec 17;12(12):3206. doi: 10.3390/diagnostics12123206.

Abstract

Primary aldosteronism (PA) is the most frequent cause of secondary hypertension. Early diagnoses of PA are essential to avoid the long-term negative effects of elevated aldosterone concentration on the cardiovascular and renal system. In this work, we study the texture of the carotid artery vessel wall from longitudinal ultrasound images in order to automatically distinguish between PA and essential hypertension (EH). The texture is characterized using 140 Haralick and 10 wavelet features evaluated in a region of interest in the vessel wall, followed by the XGBoost classifier. Carotid ultrasound studies were carried out on 33 patients aged 42-72 years with PA, 52 patients with EH, and 33 normotensive controls. For the most clinically relevant task of distinguishing PA and EH classes, we achieved a classification accuracy of 73% as assessed by a leave-one-out procedure. This result is promising even compared to the 57% prediction accuracy using clinical characteristics alone or 63% accuracy using a combination of clinical characteristics and intima-media thickness (IMT) parameters. If the accuracy is improved and the method incorporated into standard clinical procedures, this could eventually lead to an improvement in the early diagnosis of PA and consequently improve the clinical outcome for these patients in future.

摘要

原发性醛固酮增多症(PA)是继发性高血压最常见的病因。PA的早期诊断对于避免醛固酮浓度升高对心血管和肾脏系统产生长期负面影响至关重要。在这项研究中,我们从纵向超声图像研究颈动脉血管壁的纹理,以便自动区分PA和原发性高血压(EH)。通过在血管壁感兴趣区域评估的140个哈勒克特征和10个小波特征对纹理进行表征,随后使用XGBoost分类器。对33名年龄在42 - 72岁的PA患者、52名EH患者和33名血压正常的对照者进行了颈动脉超声研究。对于区分PA和EH类别这一最具临床相关性的任务,通过留一法评估,我们实现了73%的分类准确率。与仅使用临床特征时57%的预测准确率或使用临床特征与内膜中层厚度(IMT)参数相结合时63%的准确率相比,这一结果很有前景。如果准确率得到提高且该方法纳入标准临床程序,这最终可能会改善PA的早期诊断,并进而改善这些患者未来的临床结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d3/9777625/948a6133546f/diagnostics-12-03206-g001.jpg

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