Laboratory of Innovative Toxicological Research and Analyses, Institute of Medical Studies, Medical College, Rzeszów University, Aleja Majora W. Kopisto 2a, 35-959 Rzeszow, Poland.
Department of Regulatory and Forensic Toxicology, Institute of Medical Expertises, Aleksandrowska 67/93, 91-205 Łódź, Poland.
Int J Environ Res Public Health. 2022 Dec 9;19(24):16564. doi: 10.3390/ijerph192416564.
The purpose of our studies is the evaluation of the health risks of the novel elemental impurities (Ag, Au, Co, Cs, Li, Mo, Se, Sr, and V) in mint tea infusions ( L.) available in Poland. For this purpose, we applied ICP-MS-based methodology for content analysis (elemental profile and µg/L of the infusion) and also the specific health risk assessment for a comprehensive assessment. Our strategy was based on weekly intake (µg/L of infusion/week) considering weekly tea consumption. Then, based on the weekly consumption of tea per adult, individuals were compared to the Temporary Tolerated Weekly Intake (PTWI) designated by the Joint FAO Expert Committee on Food Additives (JECFA), and the weekly consumption per body weight (µg/L of infusion/week/bw) was estimated. Daily exposure to Co in the tested products is in a range of 0.093-0.238 µg/day. In comparison, the established PDE (oral exposure) for Co by the ICH guideline (the ICH guideline Q3D (R1), 2019) is 50 µg/day. For lithium, PDE is approximately 560 µg/day and, in our study, the estimated daily exposure for Li in investigated products is in a range of 0.226-2.41 µg/day. Our studies found also low levels of Cs (in a range of 0.0598-0.195 µg/L), Mo (in a range of 0.663-3.261 µg/L), and Sr (0.223-65.842 µg/L) in infusions. For Molybdenum, the established PDE is approximately 3400 µg/day. There are no documents about Sr and Co in the Joint FAO/WHO Expert Committee on Food Additives (JECFA) database and the ICH guideline Q3D (R1). In the case of V, the established PDE is 120 µg/day, and the level of V in analyzed infusions is in a range of 0.284-0.702 µg/L. Silver and gold were present only in a few samples, and the estimated daily exposure for Ag is approximately 0.04575 µg/day for product A and approximately 0.1885 µg/day for product O, except for Au, which is in a range of 0.000356-0.114 µg/L. The estimated daily exposure for Ag is 167 µg/day and, for Au, it is in a range of 8.9 × 10-0.0285 µg/day. It can be concluded that levels of all investigated elements (novel and also traditional elemental impurities) in the daily dose should not threaten the consumer's health after consuming mint tea infusions.
我们研究的目的是评估波兰薄荷茶（L.）中新型元素杂质（Ag、Au、Co、Cs、Li、Mo、Se、Sr 和 V）的健康风险。为此，我们应用了基于 ICP-MS 的含量分析方法（元素分布和 µg/L 的茶液），并进行了特定的健康风险评估，以进行全面评估。我们的策略是基于每周的摄入量（µg/L 的茶液/周），考虑每周的茶消费量。然后，根据成年人每周的茶消费量，将个体与食品添加剂联合专家委员会（JECFA）指定的暂定每周耐受摄入量（PTWI）进行比较，并估计每周每单位体重的摄入量（µg/L 的茶液/周/体重）。在测试产品中，钴的日摄入量在 0.093-0.238 µg/天之间。相比之下，ICH 指南（ICH 指南 Q3D（R1），2019 年）规定的钴的经口暴露暂定每日摄入量（PDE）为 50 µg/天。对于锂，PDE 约为 560 µg/天，而在我们的研究中，在所研究产品中估计的每日 Li 暴露量在 0.226-2.41 µg/天之间。我们的研究还发现，茶液中 Cs（0.0598-0.195 µg/L）、Mo（0.663-3.261 µg/L）和 Sr（0.223-65.842 µg/L）的含量较低。对于钼，规定的 PDE 约为 3400 µg/天。在食品添加剂联合专家委员会（JECFA）数据库和 ICH 指南 Q3D（R1）中都没有关于 Sr 和 Co 的文件。对于 V，规定的 PDE 为 120 µg/天，分析茶液中的 V 含量在 0.284-0.702 µg/L 之间。银和金仅在少数样品中存在，A 产品中 Ag 的日估计摄入量约为 0.04575 µg/天，O 产品中 Ag 的日估计摄入量约为 0.1885 µg/天，Au 除外，其含量在 0.000356-0.114 µg/L 之间。Ag 的日估计摄入量为 167 µg/天，Au 的日估计摄入量在 8.9×10-0.0285 µg/天之间。可以得出结论，在摄入薄荷茶后，所有研究元素（新型和传统元素杂质）的每日剂量都不应威胁消费者的健康。
Zotero 插件