东欧人群早孕时的下生殖道微生物群
Lower Genital Tract Microbiome in Early Pregnancy in the Eastern European Population.
作者信息
Gryaznova Mariya, Lebedeva Olga, Kozarenko Olesya, Smirnova Yuliya, Burakova Inna, Syromyatnikov Mikhail, Maslov Alexander, Popov Vasily
机构信息
Laboratory of Metagenomics and Food Biotechnology, Voronezh State University of Engineering Technologies, 394036 Voronezh, Russia.
Department of Genetics, Cytology and Bioengineering, Voronezh State University, 394018 Voronezh, Russia.
出版信息
Microorganisms. 2022 Nov 30;10(12):2368. doi: 10.3390/microorganisms10122368.
BACKGROUND
It is known that the features of the cervicovaginal microbiome can depend on ethnicity, which might be caused by genetic factors, as well as differences in diet and lifestyle. There is no research on the cervicovaginal microbiome of Eastern European women during early pregnancy.
METHODS
We evaluated the cervical and cervicovaginal microbiome of women with first-trimester pregnancy ( = 22), further delivered at term, using the sequencing method.
RESULTS
The predominant bacterial species in both groups was , followed by , , and in the cervical samples, and , , , and in the cervicovaginal samples. The cervical microbiome had higher alpha diversity; a higher abundance of and ; and a lower abundance of .
CONCLUSIONS
The -dominated microbiome (CST III) was the predominant type of cervical and cervicovaginal microbiome in early pregnancy in the majority of the women. The presence of soil and animal bacteria in the cervicovaginal microbiome can be explained by the rural origin of patients.
背景
已知宫颈阴道微生物群的特征可能取决于种族，这可能由遗传因素以及饮食和生活方式的差异引起。目前尚无关于东欧女性孕早期宫颈阴道微生物群的研究。
方法
我们使用测序方法评估了孕早期（n = 22）且足月分娩的女性的宫颈和宫颈阴道微生物群。
结果
两组中主要的细菌种类均为卷曲乳酸杆菌，宫颈样本中其次为惰性乳酸杆菌、加氏乳酸杆菌、嗜酸乳酸杆菌和詹氏乳酸杆菌，宫颈阴道样本中其次为惰性乳酸杆菌、詹氏乳酸杆菌、嗜酸乳酸杆菌、加氏乳酸杆菌和卷曲乳酸杆菌。宫颈微生物群具有更高的α多样性；卷曲乳酸杆菌和惰性乳酸杆菌丰度更高；加氏乳酸杆菌丰度更低。
结论
在大多数女性中，以卷曲乳酸杆菌为主的微生物群（CST III）是孕早期宫颈和宫颈阴道微生物群的主要类型。宫颈阴道微生物群中存在土壤和动物细菌可由患者的农村出身来解释。
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