Nguyen H P, Ho N T, Buchmann M, Kesselring U W
Institut d'Analyse Pharmaceutique, Ecole de Pharmacie, Université de Lausanne, Switzerland.
J Pharm Sci. 1987 May;76(5):406-10. doi: 10.1002/jps.2600760514.
For the first time, the total and partial solubility parameters, delta t, delta d, and delta s, of caffeine, theophylline, and methyl p-hydroxybenzoate were obtained by gas-solid chromatography (from the adsorption internal energy), by using the Keller, Karger, and Snyder equation. In comparison with the solubilization techniques, this method has the advantage of giving single solubility parameter values. The experimental work has been reduced to a minimum by the optimization of the matrix of experiments, according to the D-criterion, without any diminution in the quality of the results.
首次通过气固色谱法（从吸附内能），利用凯勒、卡格尔和斯奈德方程，获得了咖啡因、茶碱和对羟基苯甲酸甲酯的总溶解度参数和部分溶解度参数（δt、δd和δs）。与增溶技术相比，该方法的优点是能给出单一的溶解度参数值。根据D准则对实验矩阵进行优化，将实验工作量减至最少，同时结果质量没有任何下降。
