国际预后评分和 HIV 状态可预测霍奇金淋巴瘤患者红细胞浓缩液的输血需求。
The International Prognostic Score and HIV status predict red cell concentrate transfusion needs in Hodgkin lymphoma.
机构信息
Department of Medicine, Division of Clinical Haematology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Department of Radiation Oncology, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
出版信息
Leuk Lymphoma. 2023 Mar;64(3):613-620. doi: 10.1080/10428194.2022.2157214. Epub 2022 Dec 23.
Despite the burden of anemia among Hodgkin lymphoma (HL) patients, data evaluating red cell concentrate transfusion are limited. We retrospectively studied 285 newly diagnosed HL patients who received first-line adriamycin, bleomycin sulfate, vinblastine sulfate, and dacarbazine (ABVD) treatment at Groote Schuur Hospital, Cape Town. HIV prevalence in the cohort was 39.5% and 74.2% of patients had advanced stage HL. Patient prognosis was scored using the HL International Prognostic Score (IPS-7) and HL IPS-3. Seventy (24.6%) patients were transfused with a median of 2 (IQR 1-5) units per patient. Compared to HIV-negative patients, more HIV-positive patients were transfused (14.1% vs. 40.4%, < .001) and received more units, median 2 (IQR 1-3) vs. 3 (IQR 2-5), = .035. HL IPS-7 (OR 2.1, < .001) and HL IPS-3 (OR 2.6, < .001) were independently associated with transfusion. HL IPS-7, HL IPS-3, and HIV positivity remained associated with transfusion after adjusting for covariates. For patients with newly diagnosed HL, HL IPS-7, HL IPS-3, and HIV status predicted transfusion.
尽管霍奇金淋巴瘤 (HL) 患者存在贫血负担，但评估红细胞浓缩物输血的数据有限。我们回顾性研究了 285 名在开普敦格罗特舒尔医院接受一线阿霉素、博来霉素硫酸盐、长春碱硫酸盐和达卡巴嗪 (ABVD) 治疗的新诊断 HL 患者。队列中的 HIV 患病率为 39.5%，74.2%的患者处于晚期 HL。使用 HL 国际预后评分 (IPS-7) 和 HL IPS-3 对患者预后进行评分。70 名 (24.6%) 患者接受输血，中位数为每位患者 2 个单位 (IQR 1-5)。与 HIV 阴性患者相比，更多的 HIV 阳性患者接受了输血 (14.1% vs. 40.4%， < .001)，并且输注的单位数更多，中位数为 2 (IQR 1-3) vs. 3 (IQR 2-5)， = .035。HL IPS-7 (OR 2.1， < .001) 和 HL IPS-3 (OR 2.6， < .001) 与输血独立相关。在调整协变量后，HL IPS-7、HL IPS-3 和 HIV 阳性仍然与输血相关。对于新诊断的 HL 患者，HL IPS-7、HL IPS-3 和 HIV 状态预测了输血。
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