School of Nursing, Jilin University, Changchun, China.
Department of Pharmacology, College of Basic Medical Sciences, Jilin University, Changchun, China.
Age Ageing. 2022 Dec 5;51(12). doi: 10.1093/ageing/afac286.
interventions targeting older adults with cognitive frailty have grown rapidly in recent years with inconsistent findings. However, there is no meta-analysis that has synthesised pooled estimates.
to synthesise the pooled effect of current targeted interventions in older people with cognitive frailty.
we conducted a systematic search in PubMed, Embase, Web of Science, the Cochrane Library, the JBI database and three Chinese databases (CNKI, Wan-Fang and VIP) for literature from the inception of the database until 8 March 2022. The mean difference or standardised mean difference with 95% CIs was calculated. The methodological quality was assessed by the Cochrane RoB 2.0. The certainty of evidence was assessed using the GRADE criteria.
thirteen randomised controlled trials with a total of 1,089 participants were included. The results of the meta-analysis showed that older adults with cognitive frailty in the intervention groups had significant improvement in frailty score [MD = -1.67, 95% CI (-2.39, -0.95), P < 0.00001, I2 = 97%], global cognitive function [MD = 3.38, 95% CI (1.90, 4.85), P < 0.00001, I2 = 93%], mobility [MD = -0.96, 95% CI (-1.27, -1.66), P < 0.00001, I2 = 0%], muscle strength [SMD = 0.75, 95% CI (0.09, 1.41), P = 0.03, I2 = 85%] and nutritional status [MNA:MD = 5.64, 95% CI (3.99, 7.29), P < 0.00001, I2 = 89%; ALB: MD = 3.23, 95% CI (0.76, 5.71), P = 0.01, I2 = 93%; PALB: MD = 54.52, 95% CI (25.26, 83.77), P = 0.0003, I2 = 96%; TRF: MD = 0.64, 95% CI (0.22, 1.06), P = 0.003, I2 = 97%]. The overall certainty of the evidence ranged from low to moderate.
interventions targeting older adults with cognitive frailty are effective in improving physical frailty, global cognitive function, physical function and nutritional status with low to moderate certainty. More research is still needed in the future to further enrich the evidence in these fields.
CRD42022318758.
近年来，针对认知脆弱老年人的干预措施迅速增多，但研究结果并不一致。然而，目前尚无荟萃分析综合汇总这些研究结果。
综合评估针对认知脆弱老年人的现有靶向干预措施的效果。
我们对 PubMed、Embase、Web of Science、Cochrane 图书馆、JBI 数据库和三个中文数据库（CNKI、万方和 VIP）进行了系统检索，检索时间从数据库建立到 2022 年 3 月 8 日。使用均数差或标准化均数差及其 95%置信区间来计算合并效应量。使用 Cochrane RoB 2.0 评估方法学质量。使用 GRADE 标准评估证据的确定性。
纳入了 13 项随机对照试验，共 1089 名参与者。荟萃分析结果表明，干预组认知脆弱的老年人在衰弱评分[MD=-1.67，95%CI（-2.39，-0.95），P<0.00001，I2=97%]、总体认知功能[MD=3.38，95%CI（1.90，4.85），P<0.00001，I2=93%]、移动能力[MD=-0.96，95%CI（-1.27，-1.66），P<0.00001，I2=0%]、肌肉力量[SMD=0.75，95%CI（0.09，1.41），P=0.03，I2=85%]和营养状况[MNA：MD=5.64，95%CI（3.99，7.29），P<0.00001，I2=89%；ALB：MD=3.23，95%CI（0.76，5.71），P=0.01，I2=93%；PALB：MD=54.52，95%CI（25.26，83.77），P=0.0003，I2=96%；TRF：MD=0.64，95%CI（0.22，1.06），P=0.003，I2=97%]方面均有显著改善。证据的总体确定性为低到中等。
针对认知脆弱老年人的干预措施在改善身体虚弱、总体认知功能、身体功能和营养状况方面是有效的，其确定性为低到中等。未来仍需要更多研究进一步丰富这些领域的证据。
PROSPERO 注册号：CRD42022318758。
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