Department of Ophthalmology, Çerkezköy State Hospital, Cumhuriyet Mah. Melisa sok, Forest City 1 Sitesi, B1 blok, No: 15, Çerkezköy, Tekirdağ, Turkey.
Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.
Int Ophthalmol. 2023 Jul;43(7):2257-2263. doi: 10.1007/s10792-022-02621-x. Epub 2022 Dec 27.
To evaluate the corneal biomechanical properties and central corneal thickness in patients with Graves' orbitopathy (GO).
A total of 132 eyes of 66 patients with GO and 108 eyes of 54 healthy subjects were enrolled. Eyes with GO were classified as high score clinical activity score (CAS, ≥ 3) (Group 1, n = 64) and low CAS score (< 3) (Group 2, n = 68). Corneal biomechanical parameters [corneal hysteresis (CH), corneal resistance factor (CRF)], Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) levels were measured with Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Buffalo, NY) and compared between the groups.
The mean CH values were found as 9.6 ± 1 mmHg in Group 1, 10.2 ± 0.9 mmHg in Group 2, and 11.4 ± 1.7 mmHg in the Control Group (p < 0.001). In post hoc analysis the mean CH was significantly lower in Group 1 than Group 2 and Control Group (Group 1-Group 2, p < 0.001; Group 1-Control Group, p < 0.001). The mean CRF was found as 10.5 ± 2.1 in Group 1, 10.4 ± 2.2 in Group 2, and 10.43 ± 2.0 in the Control group. There was no statistically significant difference between the groups in CRF measurements (p = 0.959). The mean IOPcc values were found as 17.1 ± 3.6 mmHg in Group 1, 15.8 ± 4.0 mmHg in Group 2 and 15.2 ± 4.1 mmHg in the Control Group. The IOPcc and IOPg measurements between all groups were statistically significant (p = 0.009, p = 0.027, respectively).
Corneal biomechanical measurements were different in the GO patients with varying CAS scores compared to healthy individuals.
评估格雷夫斯眼病（GO）患者的角膜生物力学特性和中央角膜厚度。
共纳入 66 例 GO 患者的 132 只眼和 54 例健康对照者的 108 只眼。GO 患者根据高临床活动评分（CAS，≥3）（第 1 组，n=64）和低 CAS 评分（<3）（第 2 组，n=68）进行分组。使用眼反应分析仪（ORA，美国雷赛特眼科仪器公司，纽约州布法罗）测量角膜生物力学参数[角膜滞后（CH）、角膜阻力因子（CRF）]、Goldmann 相关眼压（IOPg）和角膜补偿眼压（IOPcc）水平，并比较各组之间的差异。
第 1 组的平均 CH 值为 9.6±1mmHg，第 2 组为 10.2±0.9mmHg，对照组为 11.4±1.7mmHg（p<0.001）。在事后分析中，第 1 组的平均 CH 值明显低于第 2 组和对照组（第 1 组-第 2 组，p<0.001；第 1 组-对照组，p<0.001）。第 1 组的平均 CRF 值为 10.5±2.1mmHg，第 2 组为 10.4±2.2mmHg，对照组为 10.43±2.0mmHg。各组间 CRF 测量值无统计学差异（p=0.959）。第 1 组的平均 IOPcc 值为 17.1±3.6mmHg，第 2 组为 15.8±4.0mmHg，对照组为 15.2±4.1mmHg。所有组间的 IOPcc 和 IOPg 测量值均有统计学差异（p=0.009，p=0.027）。
与健康个体相比，不同 CAS 评分的 GO 患者的角膜生物力学测量值存在差异。
