Department of Medicine, Division of Geriatric, Hospital, Palliative, and General Internal Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Department of Medicine, Los Angeles County + University of Southern California Medical Center, Los Angeles, California, USA.
J Palliat Med. 2023 Jun;26(6):776-783. doi: 10.1089/jpm.2022.0438. Epub 2022 Dec 26.
End-stage liver disease (ESLD) patients carry heavy symptom burdens and risk receiving aggressive and sometimes unwanted care at end of life. Palliative care (PC), which aims to alleviate symptoms and facilitate goal-concordant care in serious illness, may offer substantial benefits for ESLD patients but is not widely provided. To assess the impact of PC integrated within hepatology (PCIH) services on health care utilization, advance care planning (ACP), and hospice enrollment. We compared patients who received PCIH ( = 55) to a retrospective cohort ( = 57) receiving usual care in an outpatient hepatology clinic. From June 2016 to November 2017, we enrolled patients receiving care in a U.S. public hospital clinic who met the following inclusion criteria: (1) ESLD with a Model for End-Stage Liver Disease score ≥20, (2) hepatology approval for PC referral, and (3) at least one advanced complication of ESLD. We assessed patient demographics, clinical information, health care insurance status, health care utilization, completion of psychosocial assessments, and ACP using two-sided Fisher's exact test and Mann-Whitney U tests. Patients receiving PCIH more frequently had goals of care discussions (87.3% vs. 21.2% ≤ 0.01), completed ACP documentation (56.4% vs. 7.0%, ≤ 0.01), psychosocial assessments (98.2% vs. 35.1%, ≤ 0.01), and hospice enrollment (25.5% vs. 7.0%, = 0.01). Patients receiving PCIH who were hospitalized also had fewer mean hospitalization days (13 vs. 19.7 days, ≤ 0.01). Embedding PC services in a hepatology clinic is a promising strategy to improve care for ESLD patients in public hospitals.
终末期肝病 (ESLD) 患者承受着沉重的症状负担,并在生命末期面临积极治疗和有时是不必要的治疗风险。姑息治疗 (PC) 旨在缓解症状并促进严重疾病中的目标一致治疗,可为 ESLD 患者带来实质性益处,但并未广泛应用。本研究旨在评估在肝病学中整合姑息治疗服务 (PCIH) 对医疗保健利用、预先医疗指示 (ACP) 和临终关怀登记的影响。我们将接受 PCIH 治疗的患者( = 55 名)与在门诊肝病诊所接受常规护理的回顾性队列( = 57 名)进行比较。从 2016 年 6 月至 2017 年 11 月,我们招募了在一家美国公立医院诊所接受治疗且符合以下纳入标准的患者:(1)终末期肝病模型 (MELD) 评分≥20 分的 ESLD,(2)获得 PC 转介的肝病学批准,以及(3)至少存在一种 ESLD 的晚期并发症。我们使用双侧 Fisher 精确检验和 Mann-Whitney U 检验评估患者的人口统计学信息、临床信息、健康保险状况、医疗保健利用、心理社会评估完成情况和 ACP。接受 PCIH 治疗的患者更频繁地进行了治疗目标讨论(87.3% 比 21.2%, ≤ 0.01)、完成了 ACP 记录(56.4% 比 7.0%, ≤ 0.01)、心理社会评估(98.2% 比 35.1%, ≤ 0.01)和临终关怀登记(25.5% 比 7.0%, = 0.01)。接受 PCIH 治疗且住院的患者平均住院天数也较少(13 天比 19.7 天, ≤ 0.01)。在肝病诊所中嵌入 PC 服务是改善公立医院 ESLD 患者护理的一种有前途的策略。