Costa Bárbara, Mourão Joana, Vale Nuno
OncoPharma Research Group, Center for Health Technology and Services Research (CINTESIS), Rua Doutor Plácido da Costa, 4200-450 Porto, Portugal.
Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)@Health Research Network (RISE), Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
J Pers Med. 2022 Nov 5;12(11):1846. doi: 10.3390/jpm12111846.
In this review, we aim to discuss the use and effect of five different drugs used in the induction of anesthesia in cancer patients. Propofol, fentanyl, rocuronium, sugammadex, and dexamethasone are commonly used to induce anesthesia and prevent pain during surgery. Currently, the mechanisms of these drugs to induce the state of anesthesia are not yet fully understood, despite their use being considered safe. An association between anesthetic agents and cancer progression has been determined; therefore, it is essential to recognize the effects of all agents during cancer treatment and to evaluate whether the treatment provided to the patients could be more precise. We also highlight the use of in silico tools to review drug interaction effects and safety, as well as the efficacy of the treatment used according to different subgroups of patients.
在本综述中，我们旨在讨论五种不同药物在癌症患者麻醉诱导中的使用情况及效果。丙泊酚、芬太尼、罗库溴铵、舒更葡糖钠和地塞米松常用于诱导麻醉并预防手术期间的疼痛。目前，尽管这些药物的使用被认为是安全的，但其诱导麻醉状态的机制尚未完全明确。已确定麻醉剂与癌症进展之间存在关联；因此，在癌症治疗过程中认识所有药物的作用并评估给予患者的治疗是否可以更精准至关重要。我们还强调了使用计算机工具来评估药物相互作用的效果和安全性，以及根据不同患者亚组所使用治疗方法的疗效。
