Clinical Research Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Division of Biostatistics, Institute of Health and Equity, Medical College of Wisconsin, Milwaukee, WI, USA.
J Cancer Surviv. 2024 Jun;18(3):772-780. doi: 10.1007/s11764-022-01308-7. Epub 2022 Dec 30.
To assess work status, missed time at work (absenteeism), work performance (presenteeism), and their relationship with quality of life (QOL) among long-term survivors of childhood hematopoietic cell transplant (HCT).
A single-center cross-sectional survey study of adult survivors of childhood allogeneic HCT (performed between 1985 and 2010). Work and QOL data were captured using the World Health Organization Health and Work Performance Questionnaire and the National Institutes of Health Patient Reported Outcomes Measurement Information System (PROMIS), respectively. Higher absenteeism and presenteeism scores meant higher missed time at work and productivity, respectively. PROMIS domains were scored on a T-score metric with a mean score of reference population at 50 and standard deviation of 10. Univariate linear regression was performed to study factors associated with increase in PROMIS scores.
Forty-four survivors completed the survey. Median ages at HCT and survey were 11 years (interquartile range [IQR] 7-13) and 30 years (IQR 26-34), respectively. Seventy-three percent were working, 23% were unemployed, and 4% were students. Employed survivors reported less pain and sleep disturbance. Higher absolute presenteeism was associated with less pain interference and more satisfaction with social roles and activities and physical function. Higher relative presenteeism was associated with less cognitive concerns.
We found significant associations between survivors' work status, performance, and QOL. Our findings provide an important insight on the implications of work outcomes on HCT survivors' physical, mental, and social health and emphasize the importance of longitudinal assessment of work status, performance, and QOL.
评估儿童造血细胞移植（HCT）后长期幸存者的工作状态、旷工（缺勤）、工作表现（出勤）及其与生活质量（QOL）的关系。
这是一项单中心、回顾性、横断面调查研究，对象为儿童异基因 HCT 后的成年幸存者（1985 年至 2010 年间进行）。工作和 QOL 数据分别使用世界卫生组织健康和工作表现问卷和美国国立卫生研究院患者报告结局测量信息系统（PROMIS）进行采集。较高的旷工和出勤分数分别意味着更高的旷工时间和生产力。PROMIS 各域的评分采用 T 评分度量，参考人群的平均分数为 50，标准差为 10。采用单变量线性回归分析研究与 PROMIS 评分增加相关的因素。
44 名幸存者完成了调查。HCT 时和调查时的中位年龄分别为 11 岁（四分位距 [IQR] 7-13）和 30 岁（IQR 26-34）。73%的人在工作，23%的人失业，4%的人在上学。在职幸存者报告的疼痛和睡眠障碍较少。绝对出勤分数越高，疼痛干扰越小，对社会角色和活动以及身体功能的满意度越高。相对出勤分数越高，认知问题越少。
我们发现幸存者的工作状态、表现和 QOL 之间存在显著关联。我们的研究结果提供了一个重要的见解，即工作结果对 HCT 幸存者的身体、心理和社会健康的影响，并强调了对工作状态、表现和 QOL 进行纵向评估的重要性。
