肝硬化患者经颈静脉肝内门体分流术后肌肉减少症改善的预测因素
Predictors of Improvement of Sarcopenia after Transjugular Intrahepatic Portosystemic Shunt Creation in Cirrhotic Patients.
作者信息
Huang Songjiang, Liu Jiacheng, Cai Jinzhong, Zhou Chen, Wang Yingliang, Yang Chongtu, Li Tongqiang, Chen Yang, Ju Shuguang, Wang Chaoyang, Yao Wei, Bai Yaowei, Xiong Bin
机构信息
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Interventional Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China.
出版信息
J Vasc Interv Radiol. 2023 Apr;34(4):639-644. doi: 10.1016/j.jvir.2022.12.474. Epub 2022 Dec 28.
To investigate the risk factors affecting the improvement of sarcopenia after transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients, this study retrospectively analyzed the data of 111 cirrhotic patients with sarcopenia who underwent TIPS creation. Computed tomography-based measurement of skeletal muscle area was used to calculate skeletal muscle index (SMI) in all patients at baseline and 6 months after TIPS creation. Multivariate logistic regression analysis was used to identify independent risk factors, which showed a significant increase in 6-month post-TIPS SMI compared with that at baseline in both men and women (for both, P < .001). Pre-TIPS SMI (odds ratio [OR], 0.93; 95% CI, 0.87-0.99; P = .031) and change in portal pressure gradient (OR, 1.13; 95% CI, 1.03-1.24; P = .009) were found to be independent risk factors for experiencing substantial improvement in post-TIPS SMI.
为了研究影响肝硬化患者经颈静脉肝内门体分流术（TIPS）后肌肉减少症改善情况的危险因素，本研究回顾性分析了111例行TIPS手术的肝硬化肌肉减少症患者的数据。在基线和TIPS术后6个月，对所有患者采用基于计算机断层扫描测量的骨骼肌面积来计算骨骼肌指数（SMI）。采用多因素logistic回归分析确定独立危险因素，结果显示，TIPS术后6个月男性和女性的SMI均较基线时有显著增加（两者P均<0.001）。术前SMI（比值比[OR]，0.93；95%可信区间[CI]，0.87-0.99；P = 0.031）和门静脉压力梯度变化（OR，1.13；95%CI，1.03-1.24；P = 0.009）被发现是TIPS术后SMI有显著改善的独立危险因素。
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