Zhang Peiyao, Zhang Yanling, Luo Yuan, Wang Lu, Wang Kang
Department of Radiology, China-Japan Friendship Hospital, Beijing, China.
Department of Neurology, China-Japan Friendship Hospital, Beijing, China.
Front Aging Neurosci. 2022 Dec 16;14:1055160. doi: 10.3389/fnagi.2022.1055160. eCollection 2022.
Previous studies have revealed alteration of functional connectivity (FC) in Parkinson's disease patients with anxiety (PD-A), but local brain activities associated with anxiety in Parkinson's disease (PD) patients remain to be elucidated. Regional homogeneity (ReHo) analysis was employed to investigate alterations of regional brain activities in PD-A patients.
Resting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from 42 PD-A patients, 41 PD patients without anxiety (PD-NA), and 40 age-and gender-matched healthy control (HC) subjects. ReHo analysis was used to investigate the synchronization of neuronal activities in brain regions in the three groups. The relationship between ReHo value and anxiety score in the PD-A group was also investigated.
Parkinson's disease patients with anxiety showed increased ReHo values in the bilateral frontal lobes, caudate nucleus, and anterior cingulate gyrus [Gaussian random field (GRF) correction, voxel size < 0.01, cluster size < 0.05], compared with PD-NA patients and HC subjects, but the ReHo values of the right cerebellar hemisphere and posterior cerebellar lobe decreased (GRF correction, voxel size < 0.01, cluster size < 0.05). The increased ReHo values of the right superior frontal gyrus ( = 0.633, = 0.001) and anterior cingulate gyrus ( = 0.45, = 0.01) were positively correlated with anxiety scores in PD-A patients.
The development of PD-A may be associated with dysfunctional local activities in multiple brain regions, including the frontal cortex, cerebella, basal ganglia, and limbic system. Abnormal ReHo values in these brain regions may serve as neuroimaging markers for the early diagnosis of PD-A. The results suggest that using ReHo analysis to identify functional changes in core regions may advance our understanding of the pathophysiological mechanisms underlying PD-A.
先前的研究已经揭示了帕金森病伴焦虑症（PD-A）患者功能连接（FC）的改变，但帕金森病（PD）患者中与焦虑相关的局部脑活动仍有待阐明。采用局部一致性（ReHo）分析来研究PD-A患者局部脑活动的改变。
从42例PD-A患者、41例无焦虑的PD患者（PD-NA）和40例年龄及性别匹配的健康对照（HC）受试者中获取静息态功能磁共振成像（rs-fMRI）数据。使用ReHo分析来研究三组脑区神经元活动的同步性。还研究了PD-A组中ReHo值与焦虑评分之间的关系。
与PD-NA患者和HC受试者相比，帕金森病伴焦虑症患者双侧额叶、尾状核和前扣带回的ReHo值升高[高斯随机场（GRF）校正，体素大小<0.01，簇大小<0.05]，但右侧小脑半球和小脑后叶的ReHo值降低（GRF校正，体素大小<0.01，簇大小<0.05）。PD-A患者右侧额上回（=0.633，=0.001）和前扣带回（=0.45，=0.01）的ReHo值升高与焦虑评分呈正相关。
PD-A的发生可能与包括额叶皮质、小脑、基底神经节和边缘系统在内的多个脑区的局部活动功能障碍有关。这些脑区异常的ReHo值可能作为PD-A早期诊断的神经影像学标志物。结果表明，使用ReHo分析来识别核心区域的功能变化可能会促进我们对PD-A潜在病理生理机制的理解。
