Zhejiang University of Technology, Hang Zhou, China.
PLoS One. 2023 Jan 4;18(1):e0278942. doi: 10.1371/journal.pone.0278942. eCollection 2023.
Due to the particularity of biomedical industry, it has become necessary for biomedical enterprises to seek innovative research and development (R&D) cooperation to maintain advanced technologies and products in multiple fields. Under such circumstance, the biomedical industry has gradually formed a certain cluster to promote the development of the industry. So far, the biomedical industry cluster has formed in China, mainly within the Yangtze River Delta, Pearl River Delta, and Beijing-Tianjin-Hebei three urban agglomerations. Within the industrial clusters, the frequency of innovation cooperation among enterprises, universities, research institutions, and other relevant organizations in the biomedical area is high, and the capacity for innovation cooperation is strong as well. This paper used the representative cross-section data of cooperative patents from the medical science and technology patent database of China National Knowledge Infrastructure (CNKI), researching the R&D cooperation within the three major urban agglomerations in China from 2008 to 2016 (Yangtze River Delta Urban Agglomeration, Pearl River Delta Urban Agglomeration, Beijing-Tianjin-Hebei Urban Agglomeration) on total 36 cities' spatial pattern characteristics of biomedical cooperation and the influencing factors. The spatial interaction model was used to study the spatial, economic, political, and R&D influencing factors of cross-city cooperation. The degree of aggregation showed that cross-city R&D cooperation mainly occurred in well-developed and central cities of urban agglomerations. Econometric results revealed that spatial, economic, political, and R&D bias factors did have a significant impact on the frequency of biomedical R&D cooperation across cities.
由于生物医学行业的特殊性，生物医药企业寻求创新研发（R&D）合作以保持多个领域的先进技术和产品已成为必要。在这种情况下，生物医学行业逐渐形成了一定的集群，以促进产业的发展。到目前为止，中国的生物医学产业集群主要集中在长三角、珠三角和京津冀三大城市群。在产业集群内，企业、高校、研究机构等生物医学领域相关组织之间创新合作的频率较高，创新合作的能力也较强。本文利用中国国家知识基础设施（CNKI）医学科技专利数据库中具有代表性的合作专利横剖数据，研究了 2008 年至 2016 年（长三角城市群、珠三角城市群、京津冀城市群）中国三大城市群的 36 个城市的生物医学合作的研发合作的空间格局特征及其影响因素。采用空间相互作用模型研究了跨城市合作的空间、经济、政治和研发影响因素。集聚度表明，跨城市研发合作主要发生在城市群发达和中心城市。计量经济结果表明，空间、经济、政治和研发偏向因素确实对城市间生物医学研发合作的频率有显著影响。
