Department of Implantology, Stomatological Hospital and Dental School of Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, China.
Key Laboratory of Big Data-Based Precision Medicine, School of Engineering Medicine, Beihang University, Beijing, China.
Int J Oral Sci. 2023 Jan 6;15(1):5. doi: 10.1038/s41368-022-00208-x.
Tooth number abnormality is one of the most common dental developmental diseases, which includes both tooth agenesis and supernumerary teeth. Tooth development is regulated by numerous developmental signals, such as the well-known Wnt, BMP, FGF, Shh and Eda pathways, which mediate the ongoing complex interactions between epithelium and mesenchyme. Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number; however, the underlying mechanisms remain elusive. In this review, we summarized the major process of tooth development, the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality. In addition, potential treatment approaches for tooth number abnormality based on developmental biology are also discussed. This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application.
牙齿数目异常是最常见的牙齿发育疾病之一，包括牙齿缺失和多生牙。牙齿的发育受许多发育信号的调控，如著名的 Wnt、BMP、FGF、Shh 和 Eda 途径，它们介导上皮和间充质之间持续的复杂相互作用。在这个过程中，这些关键信号的异常表达最终可能导致牙齿数目异常的发生；然而，其潜在机制仍不清楚。在这篇综述中，我们总结了牙齿发育的主要过程、机制研究的最新进展以及牙齿数目异常的新报道的临床研究。此外，还讨论了基于发育生物学的牙齿数目异常的潜在治疗方法。这篇综述不仅为临床实践中牙齿数目异常的诊断和治疗提供了参考，也为基础研究向临床应用的转化提供了便利。
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