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慢性化脓性中耳炎(CSOM)患者听力分析与微生物学检查结果的关联:一种被忽视的临床表现。

Mapping of audiometric analysis with microbiological findings in patients with chronic suppurative otitis media (CSOM): a neglected clinical manifestation.

作者信息

Dhingra Shefali, Vir Dharam, Bakshi Jaimanti, Rishi Praveen

机构信息

Department of Microbiology, BMS Block I, South Campus, Panjab University, Chandigarh, India.

Division of Speech and Hearing, Department of Otolarynology & Head & Neck Surgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

出版信息

Crit Rev Clin Lab Sci. 2023 May;60(3):212-232. doi: 10.1080/10408363.2022.2158173. Epub 2023 Jan 5.

Abstract

Otitis media (OM) is an umbrella term for a number of conditions associated with middle ear inflammation. Chronic suppurative otitis media (CSOM), a type of OM, is characterized by long-term middle ear infection with perforated ear drum and otorrhea. The most common outcome associated with it is acquired hearing impairment in infected individuals which ultimately affects their cognitive and scholastic developments. Clinically, CSOM is thought to be a sequel of re-occurring episodes of Acute otitis media (AOM). and are found to be the predominant pathogenic isolates in these patients. However, with the emergence of antibiotic resistance amongst these pathogens, the adequate evaluation and treatment of this condition has become more problematic. The disease has also been recognized as one of the neglected tropical clinical manifestations with high prevalence in school-age children, especially in poor or underprivileged countries. Moreover, untreated cases have further worsened the situation by contributing to various life-threatening complications. Thus, effective treatment and surgical strategies, as well as strengthening of hearing care algorithms along with the discovery of novel animal models for advanced clinical research, can jointly help to fight this disease. In this regard, mapping of the audiological analysis with microbiological findings in CSOM patients may help elucidate the frequency that favors growth of specific pathogens. Knowledge about this potential correlation can then support timely detection of the infection, which is perceived as one of the emerging approaches for its management. In addition to these strategies, creating a true sense of awareness among people can also help mitigate this pathological condition by facilitating early identification, prevention, and treatment. This review discusses the incidence, pathogenesis, investigations, complications, and available treatment modalities associated with CSOM.

摘要

中耳炎(OM)是一系列与中耳炎症相关病症的统称。慢性化脓性中耳炎(CSOM)是中耳炎的一种类型,其特征为长期中耳感染、鼓膜穿孔和耳漏。与之相关的最常见后果是受感染个体出现后天性听力障碍,这最终会影响他们的认知和学业发展。临床上,CSOM被认为是急性中耳炎(AOM)反复发作的后遗症。[此处原文缺失两种病原体的具体内容]被发现是这些患者中主要的致病分离株。然而,随着这些病原体中抗生素耐药性的出现,对这种病症的充分评估和治疗变得更具问题。该疾病也被认为是被忽视的热带临床表现之一,在学龄儿童中高发,尤其是在贫穷或贫困国家。此外,未经治疗的病例因导致各种危及生命的并发症而使情况进一步恶化。因此,有效的治疗和手术策略,以及加强听力护理方案,同时发现用于高级临床研究的新型动物模型,共同有助于对抗这种疾病。在这方面,将CSOM患者的听力学分析与微生物学结果进行比对,可能有助于阐明有利于特定病原体生长的频率。了解这种潜在关联随后可支持对感染的及时检测,这被视为其管理的新兴方法之一。除了这些策略外,在人们当中营造真正的认知意识,也可通过促进早期识别、预防和治疗来帮助减轻这种病理状况。本综述讨论了与CSOM相关的发病率、发病机制、检查、并发症和可用的治疗方式。

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