Key Laboratory of Systemic Innovative Research on Virus Vaccine, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.
Int J Mol Sci. 2022 Dec 22;24(1):169. doi: 10.3390/ijms24010169.
Hand-foot-and-mouth disease (HFMD) is an infectious disease of children caused by more than 20 types of enteroviruses, with most cases recovering spontaneously within approximately one week. Severe HFMD in individual children develops rapidly, leading to death, and is associated with other complications such as viral myocarditis and type I diabetes mellitus. The approval and marketing of three inactivated EV-A71 vaccines in China in 2016 have provided a powerful tool to curb the HFMD epidemic but are limited in cross-protecting against other HFMD-associated enteroviruses. This review focuses on the epidemiological analysis of HFMD-associated enteroviruses since the inactivated EV-A71 vaccine has been marketed, collates the progress in the development of multivalent enteroviruses vaccines in different technical routes reported in recent studies, and discusses issues that need to be investigated for safe and effective HFMD multivalent vaccines.
手足口病（HFMD）是一种由 20 多种肠道病毒引起的儿童传染病，大多数病例在大约一周内会自然康复。个别儿童的重症 HFMD 发展迅速，导致死亡，并伴有其他并发症，如病毒性心肌炎和 I 型糖尿病。2016 年中国批准和上市的三种肠道病毒 71 型（EV-A71）灭活疫苗为遏制手足口病疫情提供了有力工具，但对其他手足口病相关肠道病毒的交叉保护作用有限。本综述重点关注肠道病毒 71 型灭活疫苗上市后手足口病相关肠道病毒的流行病学分析，整理了近年来不同技术路线报道的多种肠道病毒疫苗研发进展，并讨论了安全有效的手足口病多价疫苗需要研究的问题。
