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手足口病相关肠道病毒与多价手足口病疫苗的研发。

Hand-Foot-and-Mouth Disease-Associated Enterovirus and the Development of Multivalent HFMD Vaccines.

机构信息

Key Laboratory of Systemic Innovative Research on Virus Vaccine, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China.

出版信息

Int J Mol Sci. 2022 Dec 22;24(1):169. doi: 10.3390/ijms24010169.

DOI:10.3390/ijms24010169
PMID:36613612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9820767/
Abstract

Hand-foot-and-mouth disease (HFMD) is an infectious disease of children caused by more than 20 types of enteroviruses, with most cases recovering spontaneously within approximately one week. Severe HFMD in individual children develops rapidly, leading to death, and is associated with other complications such as viral myocarditis and type I diabetes mellitus. The approval and marketing of three inactivated EV-A71 vaccines in China in 2016 have provided a powerful tool to curb the HFMD epidemic but are limited in cross-protecting against other HFMD-associated enteroviruses. This review focuses on the epidemiological analysis of HFMD-associated enteroviruses since the inactivated EV-A71 vaccine has been marketed, collates the progress in the development of multivalent enteroviruses vaccines in different technical routes reported in recent studies, and discusses issues that need to be investigated for safe and effective HFMD multivalent vaccines.

摘要

手足口病（HFMD）是一种由 20 多种肠道病毒引起的儿童传染病，大多数病例在大约一周内会自然康复。个别儿童的重症 HFMD 发展迅速，导致死亡，并伴有其他并发症，如病毒性心肌炎和 I 型糖尿病。2016 年中国批准和上市的三种肠道病毒 71 型（EV-A71）灭活疫苗为遏制手足口病疫情提供了有力工具，但对其他手足口病相关肠道病毒的交叉保护作用有限。本综述重点关注肠道病毒 71 型灭活疫苗上市后手足口病相关肠道病毒的流行病学分析，整理了近年来不同技术路线报道的多种肠道病毒疫苗研发进展，并讨论了安全有效的手足口病多价疫苗需要研究的问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/88d72a4af1dc/ijms-24-00169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/e78f55ccb73f/ijms-24-00169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/de23d3974af5/ijms-24-00169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/88d72a4af1dc/ijms-24-00169-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/e78f55ccb73f/ijms-24-00169-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/de23d3974af5/ijms-24-00169-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd61/9820767/88d72a4af1dc/ijms-24-00169-g003.jpg

相似文献

[1]
Hand-Foot-and-Mouth Disease-Associated Enterovirus and the Development of Multivalent HFMD Vaccines.

Int J Mol Sci. 2022-12-22

[2]
EV-A71 vaccine licensure: a first step for multivalent enterovirus vaccine to control HFMD and other severe diseases.

Emerg Microbes Infect. 2016-7-20

[3]
Recent development of enterovirus A vaccine candidates for the prevention of hand, foot, and mouth disease.

Expert Rev Vaccines. 2018-8-22

[4]
The epidemiological characteristics of enterovirus infection before and after the use of enterovirus 71 inactivated vaccine in Kunming, China.

Emerg Microbes Infect. 2021-12

[5]
Molecular epidemiology and clinical features of hand, foot and mouth disease requiring hospitalization after the use of enterovirus A71 inactivated vaccine in chengdu, China, 2017-2022: a descriptive study.

Emerg Microbes Infect. 2022-12

[6]
The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV‑A71 vaccination in Kunming, China, 2017-2020.

Sci Rep. 2022-10-11

[7]
Is a multivalent hand, foot, and mouth disease vaccine feasible?

Hum Vaccin Immunother. 2015

[8]
[Analysis on epidemiological characteristics of enterovirus 71 cases of hand-foot-mouth disease based on the active monitoring in Guangdong Province in 2011-2015].

Zhonghua Yu Fang Yi Xue Za Zhi. 2018-7-6

[9]
Effectiveness of enterovirus A71 vaccine in severe hand, foot, and mouth disease cases in Guangxi, China.

Vaccine. 2020-2-11

[10]
Effectiveness of Enterovirus 71 inactivated vaccines against hand, foot, and mouth disease: A test-negative case-control study.

Hum Vaccin Immunother. 2024-12-31

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Front Microbiol. 2025-8-6

[2]
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Int J Mol Sci. 2025-7-24

[3]
LINC2781 enhances antiviral immunity against coxsackievirus B5 infection by activating the JAK-STAT pathway and blocking G3BP2-mediated STAT1 degradation.

mSphere. 2025-7-29

[4]
Epidemiology of hand, foot, and mouth disease outbreaks before and during availability of EV-A71 vaccine in China's mainland: analysis of outbreak surveillance data from 2011 to 2023.

Lancet Reg Health West Pac. 2025-6-19

[5]
The efficacy and effectiveness of enterovirus A71 vaccines against hand, foot, and mouth disease: A systematic review and meta-analysis.

PLoS One. 2025-5-22

[6]
Circulation of non-polio enteroviruses in the Ural Federal District and Western Siberia in 2023: the return of an old foe?

Arch Virol. 2025-4-22

[7]
Characteristics and timeliness of intervention in 47 school-based enterovirus outbreaks in Zhejiang Province, China.

Front Public Health. 2025-4-3

[8]
HNB-RT-LAMP Coupled with CRISPR/Cas12a for the Simultaneous Detection of Enteroviruses and Enterovirus A71 in a Single Tube.

ACS Omega. 2025-3-26

[9]
A New Human SCARB2 Knock-In Mouse Model for Studying Coxsackievirus A16 and Its Neurotoxicity.

Viruses. 2025-3-14

[10]
Epidemiological characteristics of 5838 cases of enterovirus infection in children in Hangzhou from 2018 to 2023.

Sci Rep. 2025-3-24

本文引用的文献

[1]
Combating coxsackievirus B infections.

Rev Med Virol. 2023-1

[2]
SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functions.

Front Immunol. 2022

[3]
Enteroviral Infections in Infants.

Newborn (Clarksville). 2022

[4]
Activation of Host Cellular Signaling and Mechanism of Enterovirus 71 Viral Proteins Associated with Hand, Foot and Mouth Disease.

Viruses. 2022-10-4

[5]
Foot-and-Mouth Disease Virus: Molecular Interplays with IFN Response and the Importance of the Model.

Viruses. 2022-9-27

[6]
Promiscuous Inflammasomes: The False Dichotomy of RNA/DNA Virus-Induced Inflammasome Activation and Pyroptosis.

Viruses. 2022-9-23

[7]
The spatial-temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV‑A71 vaccination in Kunming, China, 2017-2020.

Sci Rep. 2022-10-11

[8]
Recent insights into innate immune nucleic acid sensing during viral infection.

Curr Opin Immunol. 2022-10

[9]
Coxsackievirus Protease 2A Targets Host Protease ATG4A to Impair Autophagy.

Viruses. 2022-9-13

[10]
Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response.

Sci Adv. 2022-9-16

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