尿路结石患者尿路感染的抗生素敏感性。

Antibiotic Sensitivity of Urinary Tract Infection in Patients with Urinary Calculi.

机构信息

Department of Urology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Taizhou 317000, Zhejiang, China.

Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Taizhou 317000, Zhejiang, China.

出版信息

Int J Clin Pract. 2022 Dec 21;2022:7273627. doi: 10.1155/2022/7273627. eCollection 2022.

DOI:10.1155/2022/7273627

PMID:36628152

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9797306/

Abstract

BACKGROUND

The study's objective was to determine susceptibility in individuals with urinary tract infections and stones to antibiotics and prescribe optimal antimicrobial treatment.

METHODS

Nonrepetitive strains were isolated from urine specimens obtained from 317 patients diagnosed with urinary stones from January, 2018, to December, 2021. A VITEK mass spectrometer was used for species identification, and a VITEK-compact 2 automatic microbial system was used for the antimicrobial susceptibility test (AST). Susceptibility to imipenem and cefoperazone/sodium sulbactam was tested by the disc diffusion method (K-B method). The antibiotic sensitivity of the strains was analyzed by sex and season.

RESULTS

A total of 317 patients were reviewed: 202 females (63.7%) and 115 males (36.3%). infections were observed during spring (21.8%, = 69), summer (26.2%, = 83), autumn (33.8%, = 107), and winter (18.2%, = 57). infections in females were diagnosed most often during the fall (24.3%, = 77) and during the summer in males (11.0%, = 35) ( = 0.010). Female patients responded best to levofloxacin ( = 0.014), and male patients responded best to sulfamethoxazole ( = 0.023). Seasonal variation in antibiotic sensitivity was confirmed, with significantly higher rates in the winter for cefuroxime ( = 0.002) and sulfamethoxazole ( = 0.002). Significant seasonal increases were also found in levofloxacin sensitivity during the summer ( = 0.005).

CONCLUSIONS

Highly effective antibiotics such as cefoxitin and ceftazidime should be used empirically by considering antibiotic sensitivity changes by sex, season, and year. Regional studies should be conducted frequently.

摘要

背景

本研究旨在确定尿路感染和结石患者对抗生素的敏感性，并开出最佳的抗菌治疗方案。

方法

从 2018 年 1 月至 2021 年 12 月期间，对诊断为尿路结石的 317 名患者的尿液标本中分离出非重复菌株。采用 VITEK 质谱仪进行种属鉴定，采用 VITEK-compact 2 自动微生物系统进行抗菌药物敏感性试验（AST）。采用纸片扩散法（K-B 法）检测亚胺培南和头孢哌酮/舒巴坦的药敏性。按性别和季节分析菌株的抗生素敏感性。

结果

共对 317 例患者进行了回顾性分析：女性 202 例（63.7%），男性 115 例（36.3%）。春季（21.8%，69 例）、夏季（26.2%，83 例）、秋季（33.8%，107 例）和冬季（18.2%，57 例）均有感染。女性秋季（24.3%，77 例）和男性夏季（11.0%，35 例）感染最常见（=0.010）。女性患者对左氧氟沙星的反应最好（=0.014），而男性患者对磺胺甲恶唑的反应最好（=0.023）。确认了抗生素敏感性的季节性变化，冬季头孢呋辛（=0.002）和磺胺甲恶唑（=0.002）的敏感性显著增高。夏季左氧氟沙星的敏感性也显著增加（=0.005）。