Alqahtani Sulaiman S, Alabeedi Faris M
Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Najran University, Najran, Saudi Araxbia.;
Department of Oral & Maxillofacial Surgery and Diagnostic Sciences, Faculty of Dentistry, Najran University, Najran, Saudi Araxbia.
J Popul Ther Clin Pharmacol. 2023 Jan 9;30(1):e1-e13. doi: 10.47750/jptcp.2023.1020. eCollection 2023.
Oral lichen planus (OLP) is a chronic inflammatory disease that commonly affects the skin and mucous membranes. There is a difference of opinion among clinicians about whether OLP has been associated with oral candidiasis. Nonetheless, in OLP patients, the oral candidiasis prevalence rate ranges from 7.7 to 16.6%, as established through biopsy findings, whereas 37-50% of the prevalence rate has been noticed in culture findings. Oral candidiasis has been linked to several local and systemic factors, including salivary gland dysfunction, dental prostheses, topical or inhaled corticosteroids, smoking, and the use of systemic medications. The aim was to highlight the association of Candida in patients diagnosed with OLP, correlate the use of steroid therapy, and enumerate the factors of using steroid therapy as implicated causes for oral candidiasis. A search was made using search engines such as PubMed, Scopus, Cochrane Database of Systematic Reviews, Science Citation Index, NIH Public Access, and Clarivate Analytics (Figure 1). The keywords using the research option for this field were "Oral Candidiasis" AND "Oral Lichen planus" or "Candidiasis" AND "Corticosteroids" or "Topical Corticosteroids" AND Oral Lichen planus or "Inhalation Corticosteroids" AND "Candidiasis" or "Oral Lichen planus" AND "Corticosteroids." The database search was made for the duration of 1991 to -2021 (Table 1). Additional articles were obtained regarding the literature on OLP and oral candidiasis and were considered background material. The incidence of oral candidiasis and associated lichen planus following steroid therapy enlisted by various authors has been addressed. According to the results of this study, there is a positive correlation between the presence of oral candidiasis in the OLP's patients treated with corticosteroids. Finally, this meta-analysis concluded that there is a positive correlation between the presence of Candida species in OLP and steroid medication.
口腔扁平苔藓(OLP)是一种常见的慢性炎症性疾病,通常会影响皮肤和黏膜。关于OLP是否与口腔念珠菌病有关,临床医生之间存在意见分歧。尽管如此,通过活检结果确定,OLP患者中口腔念珠菌病的患病率在7.7%至16.6%之间,而在培养结果中则发现患病率为37%-50%。口腔念珠菌病与多种局部和全身因素有关,包括唾液腺功能障碍、假牙、局部或吸入性皮质类固醇、吸烟以及全身用药。目的是强调念珠菌与诊断为OLP的患者之间的关联,关联类固醇疗法的使用,并列举使用类固醇疗法作为口腔念珠菌病潜在病因的因素。使用诸如PubMed、Scopus、Cochrane系统评价数据库、科学引文索引、美国国立医学图书馆公共获取数据库和科睿唯安分析等搜索引擎进行了检索(图1)。在该领域使用研究选项的关键词为“口腔念珠菌病”和“口腔扁平苔藓”,或“念珠菌病”和“皮质类固醇”,或“局部皮质类固醇”和“口腔扁平苔藓”,或“吸入性皮质类固醇”和“念珠菌病”,或“口腔扁平苔藓”和“皮质类固醇”。在1991年至2021年期间进行了数据库检索(表1)。还获得了关于OLP和口腔念珠菌病文献的其他文章,并将其视为背景材料。讨论了不同作者列举的类固醇治疗后口腔念珠菌病和相关扁平苔藓的发病率。根据本研究结果,接受皮质类固醇治疗的OLP患者中口腔念珠菌病的存在呈正相关。最后,这项荟萃分析得出结论,OLP中念珠菌属的存在与类固醇药物之间存在正相关。