The prognostic significance of expression at diagnosis in adult Ph-negative B-cell precursor acute lymphoblastic leukemia.

The prognostic significance of cytokine receptor like factor 2 () expression at diagnosis in adult B-cell precursor acute lymphoblastic leukemia (BCP-ALL) needs to be clarified. A total of 357 bone marrow samples collected from consecutive adult cases with Ph-negative BCP-ALL at diagnosis retrospectively detected transcript levels by real-time quantitative PCR. Twenty percent was selected as the cutoff value for to divide patients into _H and _L groups. _H was associated with higher WBC count, fusion and deletions (del). In both the whole cohort and B-other patients, _H independently predicted lower CR rates after induction. Furthermore, _H/del(+) patients had significantly lower CR, RFS, and OS rates and tended to have lower RFS and OS rates than others in the whole cohort and B-other patients, respectively. Therefore, coexistence of _H and del at diagnosis predicts poor response and outcome in adult Ph-negative BCP-ALL.