从社区到核苷酸——肥胖差异系统流行病学模型的进展与差距
Neighborhoods to Nucleotides - Advances and gaps for an obesity disparities systems epidemiology model.
作者信息
Jankowska Marta M, Gaulton Kyle, Knight Rob, Patrick Kevin, Sears Dorothy D
机构信息
Qualcomm Institute/Calit2, 9500 Gilman Drive MC 0811, University of California San Diego, San Diego, CA, USA, 92093-0811.
Department of Pediatrics, UC San Diego, San Diego, CA, USA.
出版信息
Curr Epidemiol Rep. 2019 Dec;6(4):476-485. doi: 10.1007/s40471-019-00221-5. Epub 2019 Oct 30.
PURPOSE OF REVIEW
Disparities in obesity rates in the US continue to increase. Here we review progress and highlight gaps in understanding disparities in obesity with a focus on the Hispanic/Latino population from a systems epidemiology framework. We review seven domains: environment, behavior, biomarkers, nutrition, microbiome, genomics, and epigenomics/transcriptomics. We focus on recent advances that include at least two or more of these domains, and then provide a real world example of data collection efforts that reflect these domains.
RECENT FINDINGS
Research into DNA methylation related to discrimination and microbiome relating to eating behaviors and food content is furthering understanding of why disparities in obesity persist. Environmental and neighborhood level research is uncovering the importance of exposures such as air and noise pollution and systematic or structural racism for obesity and related outcomes through behaviors such as sleep.
综述目的
美国肥胖率的差异持续增加。在此，我们从系统流行病学框架出发，回顾在理解肥胖差异方面取得的进展并突出差距，重点关注西班牙裔/拉丁裔人群。我们回顾七个领域：环境、行为、生物标志物、营养、微生物组、基因组学以及表观基因组学/转录组学。我们聚焦于近期进展，这些进展涵盖至少两个或更多上述领域，然后提供一个反映这些领域的数据收集工作的实际案例。
近期发现
对与歧视相关的DNA甲基化以及与饮食行为和食物成分相关的微生物组的研究，正在加深我们对肥胖差异持续存在原因的理解。环境和社区层面的研究正在揭示诸如空气和噪音污染以及系统性或结构性种族主义等暴露因素，通过睡眠等行为对肥胖及相关结果的重要性。
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