Department of Anthropology, University of Oklahoma, Norman, OK 73019.
Laboratories of Molecular Anthropology and Microbiome Research, University of Oklahoma, Norman, OK 73019.
Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2209476119. doi: 10.1073/pnas.2209476119. Epub 2023 Jan 17.
This perspective draws on the record of ancient pathogen genomes and microbiomes illuminating patterns of infectious disease over the course of the Holocene in order to address the following question. How did major changes in living circumstances involving the transition to and intensification of farming alter pathogens and their distributions? Answers to this question via ancient DNA research provide a rapidly expanding picture of pathogen evolution and in concert with archaeological and historical data, give a temporal and behavioral context for heath in the past that is relevant for challenges facing the world today, including the rise of novel pathogens.
本观点借鉴了古代病原体基因组和微生物组的记录,阐明了全新世期间传染病的流行模式,以期回答以下问题。涉及向农业过渡和农业集约化的生活环境的重大变化如何改变病原体及其分布?通过古 DNA 研究对这个问题的解答提供了病原体进化的快速扩展图,并且与考古学和历史数据相结合,为过去的健康状况提供了时间和行为背景,这与当今世界面临的挑战有关,包括新型病原体的出现。