引产活跃期持续使用与停用缩宫素刺激：CONDISOX试验中与开放标签缩宫素转换率意外高相关的因素。
Continued versus discontinued oxytocin stimulation in the active phase of induced labour: Factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial.
作者信息
Steer Philip J, Glavind Julie, Uldbjerg Niels, Bor Pinar, Boie Sidsel
机构信息
Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, London, UK.
Department of Obstetrics and Gynaecology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
BJOG. 2023 May;130(6):636-642. doi: 10.1111/1471-0528.17376. Epub 2023 Jan 25.
OBJECTIVE
To examine the factors associated with unexpectedly high rates of conversion to open label oxytocin in the CONDISOX trial of continuation versus discontinuation of oxytocin infusion during induced labour.
DESIGN
Secondary retrospective analysis of data from a prospective randomised controlled trial.
SETTING
Nine hospitals in Denmark and one in the Netherlands between 8 April 2016 and 30 June 2020.
POPULATION OR SAMPLE
1200 women having labour induced.
METHODS
Analysis of outcomes by actual management.
MAIN OUTCOME MEASURES
Mode of delivery and associated variables.
RESULTS
Switching to open label oxytocin (42.4% overall) was associated with nulliparity, an unripe cervix, larger babies and higher rates of delivery by caesarean section.
CONCLUSIONS
In the CONDISOX trial, slow labour was associated with features suggesting a higher 'resistance to progress', often prompting the use of open-label oxytocin infusion rather than study medication.
目的
在缩宫素引产期间继续使用与停用缩宫素的CONDISOX试验中，研究与开放标签缩宫素转化率意外偏高相关的因素。
设计
对一项前瞻性随机对照试验的数据进行二次回顾性分析。
地点
2016年4月8日至2020年6月30日期间丹麦的9家医院和荷兰的1家医院。
研究对象或样本
1200名引产妇女。
方法
根据实际管理情况分析结局。
主要结局指标
分娩方式及相关变量。
结果
转为开放标签缩宫素（总体为42.4%）与初产、宫颈未成熟、胎儿较大及剖宫产率较高有关。
结论
在CONDISOX试验中，产程缓慢与提示“进展阻力”较高的特征有关，这通常促使使用开放标签缩宫素输注而非研究用药。
Zotero 插件