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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nicolantonio R D, Spargo S, Morgan T O

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):233-5. doi: 10.1111/j.1440-1681.1987.tb00381.x.

An examination was made of the effect of prenatal, high salt (5% w/w) and low salt (0.1% w/w) diet on the blood pressure and ability to excrete a salt load of mature spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on normal salt (0.8% w/w) diet after weaning. 2. Prenatal high salt diet resulted in a significant exacerbation of the hypertension of 4 month old SHR when compared with animals given prenatal low salt diet. 3. Three month old SHR given prenatal, high salt diet exhibited a significantly reduced Na+ excretion following a single, oral salt load (150 mmol/l, 1% bodyweight) when compared with the low salt group. 4. Thus, prenatal, high salt diet may influence body fluid homeostasis in genetically susceptible individuals later in life.

对冈本品系成熟自发性高血压大鼠（SHR）断奶后维持在正常盐（0.8% w/w）饮食条件下，产前高盐（5% w/w）和低盐（0.1% w/w）饮食对其血压及排泄盐负荷能力的影响进行了研究。2. 与产前给予低盐饮食的动物相比，产前高盐饮食导致4月龄SHR的高血压显著加重。3. 与低盐组相比，产前给予高盐饮食的3月龄SHR在单次口服盐负荷（150 mmol/l，1%体重）后，Na+排泄显著减少。4. 因此，产前高盐饮食可能会影响遗传易感性个体后期的体液稳态。

Nicolantonio R D, Spargo S, Morgan T O

Department of Physiology, University of Melbourne, Parkville, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):233-5. doi: 10.1111/j.1440-1681.1987.tb00381.x.

An examination was made of the effect of prenatal, high salt (5% w/w) and low salt (0.1% w/w) diet on the blood pressure and ability to excrete a salt load of mature spontaneously hypertensive rats (SHR) of the Okamoto strain maintained on normal salt (0.8% w/w) diet after weaning. 2. Prenatal high salt diet resulted in a significant exacerbation of the hypertension of 4 month old SHR when compared with animals given prenatal low salt diet. 3. Three month old SHR given prenatal, high salt diet exhibited a significantly reduced Na+ excretion following a single, oral salt load (150 mmol/l, 1% bodyweight) when compared with the low salt group. 4. Thus, prenatal, high salt diet may influence body fluid homeostasis in genetically susceptible individuals later in life.

对冈本品系成熟自发性高血压大鼠（SHR）断奶后维持在正常盐（0.8% w/w）饮食条件下，产前高盐（5% w/w）和低盐（0.1% w/w）饮食对其血压及排泄盐负荷能力的影响进行了研究。2. 与产前给予低盐饮食的动物相比，产前高盐饮食导致4月龄SHR的高血压显著加重。3. 与低盐组相比，产前给予高盐饮食的3月龄SHR在单次口服盐负荷（150 mmol/l，1%体重）后，Na+排泄显著减少。4. 因此，产前高盐饮食可能会影响遗传易感性个体后期的体液稳态。