Liposomes are spherical vesicles with a wide range of sizes from nano- to micrometer scale. For the past 7-8 decades, these vesicles have gained the interest of many scientists due to their physical, chemical, and mathematical properties and for their immense utility and potential as delivery vehicles for toxic and non-toxic excipients into biological tissues. Methods related to the selection of reagents for the creation of specific liposomes of certain properties are beyond the scope of this chapter, but here, I would outline a simplistic protocol to prepare and qualify a uniform batch of simple liposomes with basic cargo. This chapter will attempt to provide the reader with a starting point for this immensely potent tool.