Santos-Moreno Pedro, Arias-Aponte Julián, Rodríguez-Vargas Gabriel-Santiago, Nieto-Zambrano Paula Daniela, Villarreal Laura, Ibatá Linda, Martinez Susan, Rubio-Rubio Jaime-Andrés, Rodríguez Pedro, Rojas-Villarraga Adriana
Scientific Direction, Biomab Center for Rheumatoid Arthritis, Bogotá, D.C., 110221, Colombia.
Research Vice-rectory, Fundación Universitaria de Ciencias de La Salud-FUCS, Bogotá D.C, 111411, Colombia.
J Transl Autoimmun. 2023 Jan 3;6:100187. doi: 10.1016/j.jtauto.2022.100187. eCollection 2023.
To assess the frequency of polyautoimmunity (PolyA) in a cohort of Colombian patients with systemic lupus erythematosus (SLE) and to identify associated factors.
This is an analytical cross-sectional study in a specialized center., a comprehensive review of the medical records of SLE patients was performed from 2015 to 2020 in order to obtain demographic, clinical data, laboratory, and treatment information. Associations between PolyA, demographic, and characteristics of the disease were explored.
A total of 463 patients were included in the analysis. The average age was 47.3 ± 15 years. Most of this population were female (87.4%), whom were diagnosed with SLE in a long-term SLE (10.6 ± 10.1 years). Out of the total patients, 34.7% were diagnosed with PolyA. Among the most frequent clinical criteria for SLICC, arthritis (65%), kidney impairment (39.5%), and alopecia (34.8%) were found. The most frequent SLE-associated PolyA were antiphospholipid syndrome (APS) and Sjögren's syndrome (SS) (16.63% and 10.58%, respectively). PolyA-associated factors were age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis (DVT). In contrast, renal impairment was significantly less frequent in PolyA patients after multivariate analysis.
The results have showed associated factors with PolyA like age, xerophthalmia, central nervous system occlusion, and deep vein thrombosis in this cohort. On the other hand, lupus nephritis was less frequent in patients with PolyA. This study provides a spotlight of a specific SLE population as real-life evidence for a better characterization of PolyA in the future.
评估哥伦比亚系统性红斑狼疮（SLE）患者队列中多自身免疫性（PolyA）的发生率，并确定相关因素。
这是一项在专业中心进行的分析性横断面研究。对2015年至2020年SLE患者的病历进行了全面回顾，以获取人口统计学、临床数据、实验室检查和治疗信息。探讨了PolyA与人口统计学及疾病特征之间的关联。
共有463例患者纳入分析。平均年龄为47.3±15岁。该人群中大多数为女性（87.4%），她们在长期患SLE（10.6±10.1年）后被诊断出该病。在所有患者中，34.7%被诊断为PolyA。在SLICC最常见的临床标准中，发现关节炎（65%）、肾脏损害（39.5%）和脱发（34.8%）。最常见的与SLE相关的PolyA是抗磷脂综合征（APS）和干燥综合征（SS）（分别为16.63%和10.58%）。与PolyA相关的因素有年龄、干眼症、中枢神经系统闭塞和深静脉血栓形成（DVT）。相比之下，多因素分析后PolyA患者的肾脏损害明显较少见。
结果显示该队列中与PolyA相关的因素有年龄、干眼症、中枢神经系统闭塞和深静脉血栓形成。另一方面，PolyA患者中狼疮性肾炎较少见。本研究为特定SLE人群提供了一个亮点，作为未来更好地描述PolyA的真实证据。
