Khoury Elie, Acquaviva Eric, Purper-Ouakil Diane, Delorme Richard, Ellul Pierre
Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, 48 boulevard Sérurier, 75019 Paris, France.
CHU Montpellier-Saint Eloi Hospital, University of Montpellier, Unit of Child and Adolescent Psychiatry (MPEA1), 80 Av. Augustin Fliche, 34090 Montpellier, France; INSERM CESP U 1018 Psychiatry, Development and Trajectories, France.
Neurosci Biobehav Rev. 2023 Mar;146:105050. doi: 10.1016/j.neubiorev.2023.105050. Epub 2023 Jan 17.
Attention Deficit Disorder / Hyperactivity (ADHD) and Bipolar Disorder (BD) are highly comorbid disorders. Studies have raised the hypothesis of shared genetic, neurobiological, and clinical factors. This would entail an excess risk of co-occurrence of both disorders.
We present the first meta-analysis of individual and familial associations between ADHD and BD.
From 2688 references, 59 were included, with a total of 550,379 ADHD patients, 57,799 BD patients and 12,608,137 controls.
Personal history of ADHD increased the risk of BD (OR = 6.06), and conversely individuals with BD had an increased risk of ADHD (OR = 8.94). First-degree relatives of ADHD patients had an increased risk of BD (OR = 1.94). Offspring of individuals with BD had a higher risk for ADHD (OR = 2.33). Finally, first-degree relatives of BD patients had an increased risk of ADHD (OR = 2.71).
We show a clear epidemiological overlap between ADHD and BD, as well as a strong familial association which advocates in favor of a more systematic screening.
注意力缺陷多动障碍（ADHD）和双相情感障碍（BD）是高度共病的疾病。研究提出了共享遗传、神经生物学和临床因素的假设。这将导致两种疾病同时出现的风险增加。
我们首次对ADHD和BD之间的个体及家族关联进行荟萃分析。
从2688篇参考文献中，纳入了59篇，共有550379例ADHD患者、57799例BD患者和12608137例对照。
ADHD个人病史增加了患BD的风险（OR = 6.06），反之，BD患者患ADHD的风险增加（OR = 8.94）。ADHD患者的一级亲属患BD的风险增加（OR = 1.94）。BD患者的后代患ADHD的风险更高（OR = 2.33）。最后，BD患者的一级亲属患ADHD的风险增加（OR = 2.71）。
我们表明ADHD和BD之间存在明显的流行病学重叠，以及强烈的家族关联，这支持进行更系统的筛查。
