Department of Endocrinology and Metabolism, Fengxian Central Hospital Affiliated to Southern Medical University, Shanghai, 201499, P. R. China.
Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, P. R. China.
Adv Biol (Weinh). 2023 Sep;7(9):e2200234. doi: 10.1002/adbi.202200234. Epub 2023 Jan 19.
Reactive oxygen species (ROS), a by-product of mitochondrial oxidative phosphorylation and cellular metabolism, is vital for cellular survival, proliferation, damage, and senescence. In recent years, studies have shown that ROS levels and redox status in adipose tissue are strongly associated with obesity and metabolic diseases. Although it was previously considered that excessive production of ROS and impairment of antioxidant capability leads to oxidative stress and potentially contributes to increased adiposity, it has become increasingly evident that an adequate amount of ROS is vital for adipocyte differentiation and thermogenesis. In this review, by providing a systematic overview of the recent understanding of the key factors of redox systems, endogenous mechanisms for redox homeostasis, advanced techniques for dynamic redox monitoring, as well as exogenous stimuli for redox production in adipose tissues and obesity, the importance of redox biology in metabolic health is emphasized.
活性氧（ROS）是线粒体氧化磷酸化和细胞代谢的副产物，对细胞的存活、增殖、损伤和衰老至关重要。近年来的研究表明，脂肪组织中的 ROS 水平和氧化还原状态与肥胖和代谢性疾病密切相关。尽管之前认为 ROS 的过度产生和抗氧化能力的损害会导致氧化应激，并可能导致肥胖增加，但越来越明显的是，适量的 ROS 对于脂肪细胞分化和产热至关重要。在这篇综述中，通过系统地概述氧化还原系统的关键因素、氧化还原平衡的内源性机制、动态氧化还原监测的先进技术，以及脂肪组织和肥胖中氧化还原产生的外源性刺激的最新认识，强调了氧化还原生物学在代谢健康中的重要性。
