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HLA - DR抗原在移植中的作用——HLA单倍型相同供受者组合中皮肤同种异体移植物的存活情况

The role of HLA-DR antigens in transplantation--survival of skin allografts in HLA-haploidentical donor-recipient combinations.

作者信息

Dausset J, Contu L, Legrand L, Rapaport F T

出版信息

Transplant Proc. 1978 Dec;10(4):995-9.

PMID:366837
Abstract

The results of 79 skin grafts performed in haploidentical donor-recipient pairs are correlated with HLA-A, -B, -C, and -DR compatibility. A strong detrimental effect of DR incompatibilities has been demonstrated. This effect is independent from that exerted by products of the HLA-A, -B, and -C loci. An additive effect of HLA-A, -B, and -DR incompatibilities on allograft survival time has been observed.

摘要

在半相合供受者对中进行的79例皮肤移植结果与HLA - A、- B、- C和 - DR相容性相关。已证明DR不相容性具有强烈的有害作用。这种作用独立于HLA - A、- B和 - C基因座产物所发挥的作用。已观察到HLA - A、- B和 - DR不相容性对同种异体移植物存活时间具有累加效应。

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