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体重指数分组与伴有医疗保健及药物治疗费用的代谢合并症之间的关联:芬兰一项全国性生物样本库及登记研究

The association between body mass index groups and metabolic comorbidities with healthcare and medication costs: a nationwide biobank and registry study in Finland.

作者信息

Vesikansa Aino, Mehtälä Juha, Mutanen Katja, Lundqvist Annamari, Laatikainen Tiina, Ylisaukko-Oja Tero, Saukkonen Tero, Pietiläinen Kirsi H

机构信息

MedEngine Oy, Helsinki, Finland.

Novo Nordisk Farma Oy, Espoo, Finland.

出版信息

J Mark Access Health Policy. 2023 Jan 18;11(1):2166313. doi: 10.1080/20016689.2023.2166313. eCollection 2023.

Abstract

BACKGROUND

The increasing prevalence of obesity imposes a significant cost burden on individuals and societies worldwide.

OBJECTIVE

In this nationally representative study, the association between body mass index (BMI) groups and the number of metabolic comorbidities (MetC) with total direct costs was investigated in the Finnish population.

STUDY DESIGN, SETTING, AND PARTICIPANTS: The study cohort included 5,587 adults with BMI ≥18.5 kg/m who participated in the cross-sectional FinHealth 2017 health examination survey conducted by the Finnish Institute for Health and Welfare. Data on healthcare resource utilization (HCRU) and drug purchases were collected from national healthcare and drug registers.

MAIN OUTCOME MEASURE

The primary outcome was total direct costs (costs of primary and secondary HCRU and prescription medications).

RESULTS

Class I (BMI 30.0-34.9 kg/m) and class II - III (BMI ≥35.0 kg/m) obesity were associated with 43% and 40% higher age- and sex-adjusted direct costs, respectively, compared with normal weight, mainly driven by a steeply increased comorbidity in the higher BMI groups. In all BMI groups combined, individuals with ≥2 MetCs comprised 39% of the total study population and 60% of the total costs.

CONCLUSION

To manage the cost burden of obesity, treatment should be given equal consideration as other chronic diseases, and BMIs ≥30.0 kg/m should be considered in treatment decisions.

摘要

背景

肥胖症患病率的不断上升给全球个人和社会带来了巨大的成本负担。

目的

在这项具有全国代表性的研究中,调查了芬兰人群中体重指数(BMI)组与代谢合并症(MetC)数量与总直接成本之间的关联。

研究设计、地点和参与者:研究队列包括5587名BMI≥18.5kg/m²的成年人,他们参与了芬兰健康与福利研究所进行的2017年芬兰健康横断面检查调查。从国家医疗保健和药品登记处收集了医疗资源利用(HCRU)和药品购买数据。

主要结局指标

主要结局是总直接成本(初级和二级HCRU以及处方药的成本)。

结果

与正常体重相比,I类(BMI 30.0 - 34.9kg/m²)和II - III类(BMI≥35.0kg/m²)肥胖症的年龄和性别调整后的直接成本分别高出43%和40%,这主要是由较高BMI组中合并症的急剧增加所驱动。在所有BMI组中,患有≥2种MetC的个体占总研究人群的39%,占总成本的60%。

结论

为了应对肥胖症的成本负担,应将肥胖症治疗与其他慢性病同等对待,并在治疗决策中考虑BMI≥30.0kg/m²的情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6504/9858397/efe210546abd/ZJMA_A_2166313_F0001_OC.jpg

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