Mohammadi Nasibeh, Shojaeifard Maryam, Kashfi Fahimeh, Larti Farnoosh, Chenaghlou Maryam, Rezaei Yousef, Samiei Niloufar
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
North Clin Istanb. 2022 Nov 28;9(6):550-556. doi: 10.14744/nci.2021.67809. eCollection 2022.
OBJECTIVE: Pregnancy can increase gradients across the heart valves and consequently deteriorates maternal and fetoneonatal conditions. Hence, pregnancy during heart valve diseases can be challenging and we need to risk stratify patients before conception. We tried to assess the role of preconception consultation using treadmill stress echocardiography (TSE) testing for identifying pregnancy outcomes in women with mitral valve stenosis (MS) or aortic valve stenosis (AS). METHODS: Pregnant patients with a diagnosis of MS or AS were evaluated from January 2015 to December 2018. First group included patients undergoing the TSE testing and they were permitted to get pregnant if they met pre-defined criteria. Second group comprised women who did not undergo TSE testing. Maternal and fetoneonatal outcomes were also recorded. RESULTS: A total of 29 and 18 patients with MS and AS, respectively, were recruited. Among MS patients, individuals without TSE had more functional deterioration (11.1% vs. 35%) and more fetoneonatal events (FNE) (22.2% vs. 55%) compared with those undergoing TSE. The rates of maternal events and mitral valvuloplasty during pregnancy were significantly higher in patients without TSE compared with those undergoing TSE (p=0.015 and p=0.042, respectively). Among AS patients, maternal and FNE were higher in patients without TSE compared with those undergoing TSE, but those were comparable. CONCLUSION: Pregnant patients with the left-sided valvular stenosis who received preconception TSE testing had better outcomes compared with those who did not undergo preconception consultation. This underscores the utility of stress echocardiography in the risk stratification of pregnancies.
目的:妊娠会增加心脏瓣膜两侧的压力阶差,进而使母婴及胎儿-新生儿状况恶化。因此,患有心脏瓣膜疾病时妊娠可能具有挑战性,我们需要在受孕前对患者进行风险分层。我们试图评估采用平板运动负荷超声心动图(TSE)检查进行孕前咨询在识别二尖瓣狭窄(MS)或主动脉瓣狭窄(AS)女性妊娠结局中的作用。 方法:对2015年1月至2018年12月期间诊断为MS或AS的妊娠患者进行评估。第一组包括接受TSE检查的患者,若符合预定义标准则允许其怀孕。第二组包括未接受TSE检查的女性。同时记录母婴及胎儿-新生儿结局。 结果:共招募了29例MS患者和18例AS患者。在MS患者中,与接受TSE检查的患者相比,未接受TSE检查的患者功能恶化更多(11.1%对35%),胎儿-新生儿事件(FNE)更多(22.2%对55%)。未接受TSE检查的患者孕期母体事件和二尖瓣成形术的发生率显著高于接受TSE检查的患者(分别为p=0.015和p=0.042)。在AS患者中,未接受TSE检查的患者母体事件和FNE高于接受TSE检查的患者,但两者具有可比性。 结论:与未进行孕前咨询的患者相比,接受孕前TSE检查的左侧瓣膜狭窄妊娠患者结局更好。这强调了负荷超声心动图在妊娠风险分层中的作用。
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