同卵双胞胎在冲动性表型指标上的DNA甲基化差异。
Differences in DNA methylation in monozygotic twins on phenotypic indicators of impulsivity.
作者信息
Smederevac Snežana, Delgado-Cruzata Lissette, Mitrović Dušanka, Dinić Bojana M, Bravo Toni-Ann T, Delgado Maria, Bugarski Ignjatović Vojislava, Sadiković Selka, Milovanović Ilija, Vučinić Nataša, Branovački Bojan, Prinz Mechthild, Budimlija Zoran, Kušić-Tišma Jelena, Nikolašević Željka
机构信息
Department of Psychology, Faculty of Philosophy, University of Novi Sad, Novi Sad, Serbia.
John Jay College of Criminal Justice, New York, NY, United States.
出版信息
Front Genet. 2023 Jan 6;13:1067276. doi: 10.3389/fgene.2022.1067276. eCollection 2022.
Epigenetic modifications of the membrane bound catechol-O-methyltransferase (-) gene may affect the enzymatic degradation of dopamine, and consequently, human behavior. This study investigated the association between membrane bound catechol-O-methyltransferase DNA methylation (DNAm) differences in 92 monozygotic (MZ) twins with phenotypic manifestations of cognitive, behavioral, and personality indicators associated with reward-related behaviors and lack of control. We used pyrosequencing to determine DNAm of the regulatory region of membrane bound catechol-O-methyltransferase in saliva DNA. Results of intrapair differences in the percentage of membrane bound catechol-O-methyltransferase DNAm at each of five CpG sites show that there are associations between phenotypic indicators of lack of control and membrane bound catechol-O-methyltransferase DNAm differences on CpG1, CpG2 and CpG4, suggesting the common epigenetic patterns for personality traits, cognitive functions, and risk behaviors.
膜结合儿茶酚-O-甲基转移酶(-)基因的表观遗传修饰可能会影响多巴胺的酶促降解，进而影响人类行为。本研究调查了92对同卵双胞胎中膜结合儿茶酚-O-甲基转移酶DNA甲基化(DNAm)差异与认知、行为和人格指标的表型表现之间的关联，这些指标与奖励相关行为和缺乏控制有关。我们使用焦磷酸测序法来测定唾液DNA中膜结合儿茶酚-O-甲基转移酶调控区域的DNAm。五个CpG位点中每个位点的膜结合儿茶酚-O-甲基转移酶DNAm百分比的配对内差异结果表明，缺乏控制的表型指标与CpG1、CpG2和CpG4上的膜结合儿茶酚-O-甲基转移酶DNAm差异之间存在关联，这表明人格特质、认知功能和风险行为存在共同的表观遗传模式。
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