Calvino-Suarez Cristina, Ferreiro-Iglesias Rocío, Baston Rey Iria, Barreiro-de Acosta Manuel
IBD Unit, Department of Gastroenterology, University Hospital Santiago de Compostela, Galicia, Spain.
Front Med (Lausanne). 2023 Jan 4;9:1081940. doi: 10.3389/fmed.2022.1081940. eCollection 2022.
Management of ulcerative colitis after surgery suggested by guidelines (total proctocolectomy with ileal-pouch anal anastomosis) is a big challenge for physicians because patients who believed that their disease had been cured started experiencing very uncomfortable symptoms repeatedly. A high number of patients develop episodes of pouchitis, which is a non-specific inflammation of the pouch whose etiology is unknown. Antibiotics are the elective treatment for acute pouchitis, but regarding chronic pouchitis, this condition is very complicated to treat due to the absence of well-designed specific studies for this group of patients. Antibiotics, budesonide, and biological therapies are some of the recommended drugs for these patients, but despite their use, some need a permanent ileostomy.
指南建议的溃疡性结肠炎手术后的管理（全直肠结肠切除加回肠储袋肛管吻合术）对医生来说是一项巨大挑战，因为那些认为自己疾病已治愈的患者开始反复出现非常不适的症状。大量患者会发生储袋炎，这是一种储袋的非特异性炎症，其病因不明。抗生素是急性储袋炎的首选治疗方法，但对于慢性储袋炎，由于缺乏针对这类患者的精心设计的专门研究，这种情况治疗起来非常复杂。抗生素、布地奈德和生物疗法是推荐给这些患者的一些药物，但尽管使用了这些药物，一些患者仍需要永久性回肠造口术。
