Gallo J M, Lam F C, Perrier D G
Department of Pharmacy, University of Otago, Dunedin, New Zealand.
J Pharmacokinet Biopharm. 1987 Jun;15(3):271-80. doi: 10.1007/BF01066322.
A new technique, the area method, is derived for the determination of partition coefficients for both blood-flow limited and membrane limited physiological pharmacokinetic models. This method was compared to a standard technique by Monte Carlo simulation. Partition coefficients were calculated for the blood-flow limited case for both eliminating and noneliminating organs. It was found that the area method compared favorably to a standard technique and was less prone to error. This may be attributed to the more subjective interpretation as to which data points are included in the terminal phase, since the standard method relies on the accurate determination of the terminal slope for the calculation of partition coefficients. Both methods are satisfactory for the calculation of partition coefficients with the area method being more accurate and precise.
一种新的技术——面积法，被推导用于确定血流限制和膜限制生理药代动力学模型的分配系数。通过蒙特卡罗模拟将该方法与标准技术进行了比较。计算了消除器官和非消除器官在血流限制情况下的分配系数。结果发现，面积法与标准技术相比具有优势，且出错概率更低。这可能归因于在终末期应纳入哪些数据点的解释更为主观，因为标准方法在计算分配系数时依赖于终末斜率的准确测定。两种方法在计算分配系数时都令人满意，而面积法更准确、更精确。
