急性肌肉减少症。

Acute Sarcopenia.

机构信息

Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain,

出版信息

Gerontology. 2023;69(5):519-525. doi: 10.1159/000529052. Epub 2023 Jan 23.

Abstract

Sarcopenia is currently understood as an organ insufficiency. However, the distinction of acute and chronic sarcopenia as different categories, which makes sense in this conceptual framework, is still evolving. The first set of modern definitions of sarcopenia only considered chronic sarcopenia. However, research showed that function in acute care settings differs from the loss that evolves slowly over months or years, and this fact is starting to permeate modern definitions. The updated version of the EWGSOP definition identifies acute and chronic sarcopenia as subcategories. Different studies have reported rates of incident sarcopenia in hospitalised older patients around 15-20%, which adds to the prevalent sarcopenia present on admission. Diagnosing sarcopenia in acute settings carries specific challenges related to the patients, the acute condition, and limitations in the use of diagnostic tests for muscle mass, muscle strength, and physical performance. Prevention and management of acute sarcopenia rely on exercise during admission, but the quality of evidence is still low. Nutritional intervention and drugs may have a role, but more research is needed.

摘要

肌肉减少症目前被理解为一种器官功能不全。然而,在这个概念框架中,将急性和慢性肌肉减少症区分开来作为不同的类别,这是有意义的,这种区分仍在不断发展。第一组现代肌肉减少症定义仅考虑了慢性肌肉减少症。然而,研究表明,急性治疗环境中的功能与数月或数年内缓慢发展的丧失不同,这一事实开始渗透到现代定义中。EWGSOP 定义的更新版本将急性和慢性肌肉减少症确定为亚类。不同的研究报告了住院老年患者中发生的肌肉减少症的发生率约为 15-20%,这增加了入院时存在的普遍肌肉减少症。在急性环境中诊断肌肉减少症具有与患者、急性病情以及肌肉质量、肌肉力量和身体表现诊断测试的使用限制相关的特定挑战。急性肌肉减少症的预防和管理依赖于入院期间的运动,但证据质量仍然较低。营养干预和药物可能有作用,但需要更多的研究。

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