寡核苷酸治疗领域的药物化学未来方向。
Future directions for medicinal chemistry in the field of oligonucleotide therapeutics.
机构信息
Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
出版信息
RNA. 2023 Apr;29(4):423-433. doi: 10.1261/rna.079511.122. Epub 2023 Jan 24.
Abstract
In the last decade, the field of oligonucleotide therapeutics has matured, with the regulatory approval of several single-stranded and double-stranded RNA drugs. In this Perspective, I discuss enabling developments and likely future directions in the field from the perspective of oligonucleotide chemistry.
摘要
在过去的十年中，寡核苷酸治疗学领域已经成熟，有几种单链和双链 RNA 药物获得了监管批准。在这篇观点文章中，我从寡核苷酸化学的角度讨论了该领域的一些促成性发展和可能的未来方向。
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