肾移植受者中宫颈人乳头瘤病毒的患病率及肛门合并感染风险：一项丹麦临床研究的结果

Prevalence of cervical human papillomavirus and the risk of anal co-infection in kidney transplant recipients: Results from a Danish clinical study.

作者信息

Ring Linea Landgrebe, Thomsen Louise T, Haedersdal Merete, Sørensen Søren Schwartz, Bonde Jesper Hansen, Lok Trine Thorborg, Larsen Helle K, Kjaer Susanne K

机构信息

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

Department of Dermatology and Venereology, Copenhagen University Hospital, Bispebjerg Hospital, Copenhagen, Denmark.

出版信息

Transpl Infect Dis. 2023 Apr;25(2):e14019. doi: 10.1111/tid.14019. Epub 2023 Feb 7.

DOI:10.1111/tid.14019

PMID:36695181

Abstract

BACKGROUND

Kidney transplant recipients (KTRs) have increased risk of human papillomavirus (HPV)-related cancers, including cervical and anal cancer. In this cross-sectional clinical study, we investigated the prevalence of cervical high-risk HPV (hrHPV) and low-risk (lrHPV), risk factors for cervical hrHPV infection, and the prevalence of cervical and anal hrHPV co-infection in KTRs and immunocompetent controls.

METHODS

During 2016-2017, we recruited 125 female KTRs and 125 female immunocompetent controls from one dermatology department (KTRs and controls) and five nephrology departments (KTRs) in Denmark. Liquid-based cervical and anal cytology samples were tested for HPV DNA using the INNO-LiPA test and participants answered a questionnaire on lifestyle. Odds ratios (ORs) were estimated using logistic regression, adjusting for age, lifetime sexual partners, smoking, and (in models concerning anal HPV) receptive anal sex.

RESULTS

KTRs had higher prevalence of cervical hrHPV than controls (35.5% vs. 18.2; OR = 2.9, 95% CI, 1.5-5.5). In contrast, the prevalence of lrHPV was similar in KTRs and controls (25.6% vs. 23.1; OR = 1.2, 95% CI, 0.7-2.3). KTRs were more likely than controls to have cervical and anal hrHPV co-infection (27.3% vs. 6.6%, OR = 6.3, 95% CI, 2.7-15.0).

CONCLUSIONS

Female KTRs had high prevalence of cervical hrHPV, and co-infection with anal and cervical hrHPV was common. Our results underline that KTRs are an important target group for preventive efforts against HPV-related diseases.

摘要

背景

肾移植受者（KTRs）患人乳头瘤病毒（HPV）相关癌症（包括宫颈癌和肛门癌）的风险增加。在这项横断面临床研究中，我们调查了KTRs和免疫功能正常对照者中宫颈高危HPV（hrHPV）和低危HPV（lrHPV）的患病率、宫颈hrHPV感染的危险因素以及宫颈和肛门hrHPV合并感染的患病率。

方法

2016年至2017年期间，我们从丹麦的一个皮肤科（KTRs和对照者）和五个肾内科（KTRs）招募了125名女性KTRs和125名免疫功能正常的女性对照者。使用INNO-LiPA检测法对液基宫颈和肛门细胞学样本进行HPV DNA检测，参与者回答了一份关于生活方式的问卷。使用逻辑回归估计比值比（ORs），并对年龄、终身性伴侣、吸烟情况以及（在涉及肛门HPV的模型中）接受肛交情况进行校正。

结果

KTRs中宫颈hrHPV的患病率高于对照者（35.5%对18.2%；OR = 2.9，95% CI，1.5 - 5.5）。相比之下，KTRs和对照者中lrHPV的患病率相似（25.6%对23.1%；OR = 1.2，95% CI，0.7 - 2.3）。KTRs比对照者更有可能同时感染宫颈和肛门hrHPV（27.3%对6.6%，OR = 6.3，95% CI，2.7 - 15.0）。