Moran W J, Dobleman T J, Bostwick D G
Department of Otolaryngology-Head and Neck Surgery, University of Chicago Medical Center, IL 60637.
Laryngoscope. 1987 Nov;97(11):1299-302. doi: 10.1288/00005537-198711000-00009.
The first case of epithelioid hemangioendothelioma involving the oropharynx is described. A 25-year-old woman developed a mass on the palate which noted to enlarge during the first trimester of pregnancy. Biopsy revealed a cellular tumor initially considered to be of epithelial origin. Vascular differentiation of the tumor was confirmed, however, by positive lectin histochemistry for Ulex europaeus, by evidence of immunoreactivity for factor VIII-related antigen, and by ultrastructural identification of endothelial features. The patient remains free of tumor 21 months after complete excision. Because of the potential for misdiagnosis, epithelioid hemangioendothelioma should be considered in the differential diagnosis of oropharyngeal malignancies. The effect of pregnancy on the development and growth of vascular tumors such as epithelioid hemangioendothelioma remains uncertain.
本文描述了首例累及口咽的上皮样血管内皮瘤病例。一名25岁女性腭部出现肿物，在妊娠头三个月内肿物增大。活检显示为细胞性肿瘤，最初认为起源于上皮。然而，通过欧洲荆豆凝集素组织化学阳性、VIII因子相关抗原免疫反应性证据以及内皮特征的超微结构鉴定，证实了肿瘤的血管分化。患者在完全切除后21个月无肿瘤复发。由于存在误诊的可能性，在口咽恶性肿瘤的鉴别诊断中应考虑上皮样血管内皮瘤。妊娠对诸如上皮样血管内皮瘤等血管肿瘤的发生和生长的影响仍不确定。
