Mohammed Saeed Rashaad, Tripathi Mallika, Mack Narine, Teelucksingh Surujpal
Department of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago.
San Fernando General Hospital, South West Regional Health Authority, San Fernando, Trinidad and Tobago.
Med Int (Lond). 2021 Dec 21;1(5):25. doi: 10.3892/mi.2021.25. eCollection 2021 Nov-Dec.
The interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and autoimmune thyroid disease is an emerging phenomenon. The present study describes the case of a 28-year-old female who experienced a relapse of Graves' disease following SARS-CoV-2 infection. She was biochemically euthyroid for 2 years prior to COVID-19 infection. However, she began experiencing palpitations, increased sweating and tremors of the hands 9 days after being diagnosed with COVID-19-related pneumonia. In addition to presenting this case, a comparison is made of this case to similar reports and the possible mechanisms underlying the association between SARS-CoV-2 and Graves' disease are discussed. One is a direct result of viral uptake by thyroid cells, while another is a result of the hyperinflammatory 'cytokine storm' and its effects on the hypothalamic-pituitary-thyroid axis and T-cell immunity.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）与自身免疫性甲状腺疾病之间的相互作用是一个新出现的现象。本研究描述了一名28岁女性在感染SARS-CoV-2后格雷夫斯病复发的病例。在感染新冠病毒之前，她甲状腺功能生化指标正常达2年。然而，在被诊断为新冠病毒相关肺炎9天后，她开始出现心悸、多汗和手部震颤。除了呈现该病例外，还将此病例与类似报告进行了比较，并讨论了SARS-CoV-2与格雷夫斯病之间关联的可能机制。一种是甲状腺细胞摄取病毒的直接结果，另一种是高炎症性“细胞因子风暴”及其对下丘脑-垂体-甲状腺轴和T细胞免疫的影响所致。
