Department of Geriatric Medicine, Angers University Hospital; Angers University Memory Clinic; Research Center on Autonomy and Longevity; UPRES EA 4638, University of Angers, Angers, France
Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON, Canada
Geriatr Psychol Neuropsychiatr Vieil. 2022 Dec 1;20(4):407-411. doi: 10.1684/pnv.2022.1061.
The Game of Thrones fiction is particularly marked by an alarmist maxim, "Winter is coming", which highlights the fear of Westeros inhabitants as Winter approaches. The threat is such that Winter has been given the face of the Night King, whose progress threatens all life north of Westeros. The objective of this narrative review was to elucidate why the coming of Winter was so threatening, particularly by exploring the hypovitaminosis D hypothesis.
Three sources of information were consulted in April-June 2019, including PubMed, the fantasy novels A Song of Ice and Fire by George R.R. Martin, and the Game of Thrones Wiki.
As the sun is the primary source of vitamin D, lower serum 25-hydroxyvitamin D levels are typically observed during Winter. Vitamin D regulates hundreds of genes in almost all human tissues, with relevance for several diseases. Winter-induced hypovitaminosis D may thus initiate and/or exacerbate: i) diseases such as osteopathies, viral infections, cardiovascular diseases, autoimmune diseases and cancers; ii) decline of physical abilities and skills needed for physical trades or combat; iii) decline of cognition and decision-making abilities, which are necessary to carry out the game of thrones; iv) greater mortality risk threatening all humanity.
If Winter comes south of the Wall, people of all ages and conditions in Westeros would be exposed to the risks induced by hypovitaminosis D. We propose that Winter, the Night King and hypovitaminosis D are one and the same danger in Game of Thrones.
《权力的游戏》小说中有一个特别引人注目的警言，“凛冬将至”，这突出了维斯特洛居民对凛冬临近的恐惧。威胁如此之大，以至于凛冬被赋予了夜王的形象，他的到来威胁着维斯特洛以北的所有生命。本叙事综述的目的是阐明为什么凛冬的到来如此具有威胁性，特别是通过探索维生素 D 缺乏症假说。
2019 年 4 月至 6 月，我们查阅了三种信息来源，包括 PubMed、乔治·R·R·马丁的奇幻小说《冰与火之歌》以及《权力的游戏》维基。
由于太阳是维生素 D 的主要来源，因此通常在冬季观察到血清 25-羟维生素 D 水平降低。维生素 D 调节着几乎所有人类组织中的数百个基因，与多种疾病相关。冬季诱导的维生素 D 缺乏症可能会引发和/或加重：i）骨质疏松症、病毒感染、心血管疾病、自身免疫性疾病和癌症等疾病；ii）体能下降以及从事体力劳动或战斗所需的技能下降；iii）认知和决策能力下降，这对于开展权力的游戏是必要的；iv）威胁全人类的更高死亡率风险。
如果凛冬南下越过长城，维斯特洛所有年龄段和条件的人都将面临维生素 D 缺乏症引起的风险。我们提出，《权力的游戏》中的凛冬、夜王和维生素 D 缺乏症是同一危险。
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