Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, Heraklion, Crete, Greece.
University of Crete Medical School, Heraklion, Crete, Greece.
J Chemother. 2023 Nov;35(7):596-600. doi: 10.1080/1120009X.2023.2170906. Epub 2023 Jan 27.
Infections by carbapenem-resistant (CRKP) remain one of the greatest healthcare threats associated with significant morbidity and mortality. New antimicrobials were recently developed to address this threat. We assessed the epidemiology of carbapenemase-producing (CPKP) isolates recovered in a Greek university hospital during 2021, and their susceptibilities to old and newer antimicrobials. Minimum inhibitory concentrations (MICs) were determined by the MIC Test Strip method, except for cefiderocol (CFDC) and colistin that were evaluated by the broth microdilution method. A total of 110 CPKP strains were isolated, with KPC-producers being the most prevalent (64.6%). Among the agents tested, plazomicin (PL) displayed the highest activity against all the isolates (MIC/MIC, 0.5/1.5 μg/ml), followed by tigecycline (MIC/MIC, 1.5/4 μg/ml). All KPC-producing were susceptible to ceftazidime-avibactam (CAZ/AVI) and meropenem-vaborbactam (M/V) and 97.2% of them to imipenem-relebactam (I/R). Among the MBL-producing isolates, PL and CFDC exhibited the highest activity.
耐碳青霉烯肠杆菌科（CRKP）感染仍然是与高发病率和死亡率相关的最大的医疗保健威胁之一。最近开发了新的抗生素来应对这一威胁。我们评估了 2021 年希腊一家大学医院分离的产碳青霉烯酶（CPKP）分离株的流行病学情况及其对旧和新抗生素的敏感性。除头孢他啶-阿维巴坦（CAZ/AVI）和美罗培南-维巴坦（M/V）外，最小抑菌浓度（MIC）均采用 MIC 测试条法测定，多粘菌素 E 采用肉汤微量稀释法测定。共分离出 110 株 CPKP 菌株，其中 KPC 产菌株最为常见（64.6%）。在所测试的药物中，帕拉米韦（PL）对所有分离株的活性最高（MIC/MIC，0.5/1.5μg/ml），其次是替加环素（MIC/MIC，1.5/4μg/ml）。所有 KPC 产菌株均对头孢他啶-阿维巴坦（CAZ/AVI）和美罗培南-维巴坦（M/V）敏感，其中 97.2%对亚胺培南-雷巴坦（I/R）敏感。在产金属β-内酰胺酶（MBL）的分离株中，PL 和头孢他啶-阿维巴坦（CAZ/AVI）表现出最高的活性。
