Department of Radiology, Division of Interventional Radiology, Memorial Sloan Kettering Cancer Center, United States of America.
Department of Pathology, Division of Thoracic Pathology, Memorial Sloan Kettering Cancer Center, United States of America.
Clin Imaging. 2023 Mar;95:92-96. doi: 10.1016/j.clinimag.2022.12.008. Epub 2022 Dec 27.
To summarize imaging and histopathologic characteristics of hydrogel sealant (plug) in lung parenchyma and assess their correlation with time since deployment of sealant.
Among a total of 208 participants randomized to the hydrogel sealant arm of a lung biopsy prospective randomized clinical trial, 51 underwent resection of the biopsied lesion. In 34 participants sealant material was present on histopathologic sections (n = 22), or they had cross-sectional imaging of chest between biopsy and resection (n = 23) or they had both imaging and histopathology (n = 11). Histopathologic and imaging findings were described. The association of these findings with time since sealant deployment was evaluated using the Wilcoxon rank sum test.
The mean time since sealant deployment for histopathology was 45.7 days (median 36, range 14-181) and for imaging studies was 99 days (median 32, range 4-527). The sealant was infiltrated by inflammatory cells in 20 (91%) participants. The main general histopathologic pattern of sealant was foamy in 12 (57%) and mesh in 8 (38%) participants. Imaging appearance of sealant was serpiginous in 18 (60%), linear in 10 (33%) or lobulated in 2 (6.7%) participants. In 2 participants the sealant was hypermetabolic with no histopathologic evidence of tumor. No correlation was found between time since sealant deployment and imaging or histopathologic appearances.
Hydrogel sealant appears as a serpiginous, linear, or lobulated opacity on cross-sectional imaging which can be metabolically active. It is associated with an inflammatory reaction with a foamy or mesh general pattern on histopathological assessment. No correlation was found between time since sealant deployment and imaging or histopathologic appearances.
总结水凝胶密封剂（塞子）在肺实质中的影像学和组织病理学特征，并评估其与密封剂使用时间的相关性。
在一项肺活检前瞻性随机临床试验的水凝胶密封剂组中，共有 208 名参与者随机分组，其中 51 名接受了活检病变切除术。在 34 名参与者中，密封剂材料存在于组织病理学切片中（n=22），或他们在活检和切除之间有胸部横断面成像（n=23），或他们同时有影像学和组织病理学（n=11）。描述了组织病理学和影像学发现。使用 Wilcoxon 秩和检验评估这些发现与密封剂使用时间的关系。
组织病理学检查的平均密封剂使用时间为 45.7 天（中位数 36，范围 14-181），影像学研究为 99 天（中位数 32，范围 4-527）。20 名（91%）参与者的密封剂被炎症细胞浸润。密封剂的主要一般组织病理学模式为 12 名（57%）参与者的泡沫状和 8 名（38%）参与者的网状。18 名（60%）参与者的密封剂呈蛇形，10 名（33%）参与者呈线性，2 名（6.7%）参与者呈分叶状。在 2 名参与者中，密封剂代谢活跃，但无组织病理学证据表明存在肿瘤。未发现密封剂使用时间与影像学或组织病理学表现之间存在相关性。
水凝胶密封剂在横断面成像上呈蛇形、线性或分叶状不透明，可能代谢活跃。它与炎症反应有关，组织病理学评估呈泡沫状或网状一般模式。未发现密封剂使用时间与影像学或组织病理学表现之间存在相关性。
