Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, and School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, P. R. China.
Chongqing Engineering Laboratory of Nano/Micro Biomedical Detection Technology, Chongqing University of Science and Technology, Chongqing 401331, P. R. China.
ACS Appl Mater Interfaces. 2023 Feb 8;15(5):6572-6583. doi: 10.1021/acsami.2c22558. Epub 2023 Jan 29.
Antioxidant-defense systems of tumor cells protect them from oxidative damage and is strongly associated with tumor metastasis. In this work, a mussel-inspired multifunctional nanomedicine (ZS-MB@P) has been designed for inhibiting tumor growth and metastasis through amplified oxidative stress and photothermal/magnetothermal/photodynamic triple-combination therapy. This nanomedicine was fabricated loading a silica shell on the magnetic nano-octahedrons [zinc-doped magnetic FeO nano-octahedrons] by encapsulating photosensitizer methylene blue (MB) and subsequently coating polydopamine (PDA) shells as "gatekeeper." The nanomedicine could realize photothermal therapy, photodynamic therapy, and magnetic hyperthermia after treatment with near-infrared (NIR) irradiation and applied magnetic field. Under pH and NIR stimulation, controlled amount of MB was released to produced exogenous reactive oxygen species. Noteworthy, PDA can amplify intracellular oxidative stress by depleting glutathione, thus inhibiting breast cancer metastasis effectively since oxidative stress is an important barrier to tumor metastasis. The outstanding ability to suppress tumor growth and metastasis was comprehensively assessed and validated both and . Moreover, the nanomedicine showed outstanding magnetic resonance imaging for tracking the treatment process. Taken together, this work offers an innovative approach in the synergistic treatment of recalcitrant breast cancer.
肿瘤细胞的抗氧化防御系统可以保护它们免受氧化损伤，并且与肿瘤转移密切相关。在这项工作中，设计了一种贻贝启发的多功能纳米医学（ZS-MB@P），通过放大氧化应激和光热/磁热/光动力三联组合治疗来抑制肿瘤生长和转移。该纳米医学是通过在磁性纳米八面体[掺锌磁性 FeO 纳米八面体]上包覆二氧化硅壳来制备的，方法是将光敏剂亚甲蓝（MB）包封在内，然后涂覆聚多巴胺（PDA）壳作为“守门员”。纳米医学在近红外（NIR）照射和施加磁场后可以实现光热疗法、光动力疗法和磁热疗。在 pH 和 NIR 刺激下，控制 MB 的释放量以产生外源性活性氧。值得注意的是，PDA 可以通过耗尽谷胱甘肽来放大细胞内氧化应激，从而有效抑制乳腺癌转移，因为氧化应激是肿瘤转移的重要障碍。在体内和体外均对抑制肿瘤生长和转移的能力进行了综合评估和验证。此外，该纳米医学在跟踪治疗过程方面表现出出色的磁共振成像能力。综上所述，这项工作为治疗难治性乳腺癌提供了一种协同治疗的创新方法。
