Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain; UVIC, Universitat Central de Catalunya, Vic, Spain.
Servicio de Otorrinolaringología, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
Acta Otorrinolaringol Esp (Engl Ed). 2023 Jan-Feb;74(1):31-38. doi: 10.1016/j.otoeng.2022.02.008. Epub 2023 Jan 26.
The present study aims to analyse the differential characteristics of patients with head and neck squamous cell carcinoma (HNSCC) without a history of consumption of toxic substances such as tobacco and alcohol.
We carried out a retrospective study of 4694 patients with HNSCC located in the oral cavity, oropharynx, hypopharynx or larynx treated in our centre during the period 1985-2019.
7.7% of the patients (n = 363) did not report a history of consumption of toxic substances. The group of patients with no toxic history was older, had a higher proportion of women, a higher frequency of cases located in the oral cavity, a higher proportion of cases diagnosed in early stages, and a lower incidence of second neoplasms. The percentage of patients with no history of consumption of toxic substances increased significantly over the study period. The overall survival of patients with no history of consumption of toxic substances was significantly higher than that of patients with toxic substances use. Specific survival for patients with tumours located in the oral cavity without a history of consumption of toxic substances was significantly lower than that of patients with toxic substances use, whereas for patients with oropharyngeal carcinomas the absence of a history of consumption of toxic substances was associated with a better prognosis.
There were differences in the epidemiological and prognostic characteristics of patients with HNSCC according to the history of consumption of toxic substances such as tobacco and alcohol.
本研究旨在分析无吸烟和饮酒等有毒物质接触史的头颈部鳞状细胞癌（HNSCC）患者的差异特征。
我们对 1985 年至 2019 年期间在我们中心治疗的口腔、口咽、下咽或喉 HNSCC 患者的 4694 例进行了回顾性研究。
7.7%（n=363）的患者无有毒物质接触史。无有毒物质接触史组患者年龄较大，女性比例较高，口腔部位发病比例较高，早期诊断病例比例较高，第二原发癌发病率较低。无有毒物质接触史患者的比例在研究期间显著增加。无有毒物质接触史患者的总生存率显著高于有毒物质接触史患者。无有毒物质接触史的口腔肿瘤患者的特定生存率明显低于有毒物质接触史患者，而无有毒物质接触史的口咽癌患者的预后较好。
根据吸烟和饮酒等有毒物质的接触史，HNSCC 患者的流行病学和预后特征存在差异。
