Faculty of Science and Technology, Institute of Physics, University of Silesia in Katowice, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
Faculty of Science and Technology, Institute of Physics, University of Silesia in Katowice, SMCEBI, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland.
J Pharm Sci. 2023 Jun;112(6):1644-1652. doi: 10.1016/j.xphs.2023.01.020. Epub 2023 Jan 26.
This article investigated the effect of shear strain on the nematic itraconazole (ITR) from both elastic and plastic deformation regions. The rheo-dielectric technique was used for this purpose. It has been demonstrated that shear strain can change the sample color, liquid crystal alignment as well as its dielectric and thermal properties. The observed modifications depend on the shear strain value. One can distinguish four regions regarding the slope of ITR stress-strain dependence and caused changes. Proper alignment changes (obtained after the shearing procedure) can additionally affect the further recrystallization of ITR to other than the initial, i.e., second polymorphic form.
本文研究了剪切应变对弹性和塑性变形区向列型伊曲康唑（ITR）的影响。为此目的，使用了流变-介电技术。已经证明，剪切应变可以改变样品的颜色、液晶取向以及介电和热性能。观察到的变化取决于剪切应变值。关于 ITR 应力-应变关系的斜率和引起的变化，可以区分四个区域。适当的取向变化（在剪切过程后获得）还可以影响 ITR 的进一步重结晶，使其形成不同于初始的第二晶型。
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